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Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents.
Gupta SC, Prasad S, Reuter S, Kannappan R, Yadav VR, Ravindran J, Hema PS, Chaturvedi MM, Nair M, Aggarwal BB. Gupta SC, et al. Among authors: kannappan r. J Biol Chem. 2010 Nov 12;285(46):35406-17. doi: 10.1074/jbc.M110.161984. Epub 2010 Sep 9. J Biol Chem. 2010. PMID: 20829362 Free PMC article.
A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
Phromnoi K, Reuter S, Sung B, Prasad S, Kannappan R, Yadav VR, Chanmahasathien W, Limtrakul P, Aggarwal BB. Phromnoi K, et al. Among authors: kannappan r. Mol Pharmacol. 2011 Feb;79(2):279-89. doi: 10.1124/mol.110.067512. Epub 2010 Oct 7. Mol Pharmacol. 2011. PMID: 20930110 Free PMC article. Retracted.
Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer.
Reuter S, Prasad S, Phromnoi K, Ravindran J, Sung B, Yadav VR, Kannappan R, Chaturvedi MM, Aggarwal BB. Reuter S, et al. Among authors: kannappan r. Cancer Prev Res (Phila). 2010 Nov;3(11):1462-72. doi: 10.1158/1940-6207.CAPR-10-0037. Epub 2010 Oct 26. Cancer Prev Res (Phila). 2010. PMID: 20978115 Free PMC article.
Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-κB α kinase activation, leading to suppression of NF-κB-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents.
Gupta SC, Kannappan R, Kim J, Rahman GM, Francis SK, Raveendran R, Nair MS, Das J, Aggarwal BB. Gupta SC, et al. Among authors: kannappan r. Mol Pharmacol. 2011 Nov;80(5):769-81. doi: 10.1124/mol.111.073122. Epub 2011 Jul 27. Mol Pharmacol. 2011. PMID: 21795584 Free PMC article.
Zyflamend sensitizes tumor cells to TRAIL-induced apoptosis through up-regulation of death receptors and down-regulation of survival proteins: role of ROS-dependent CCAAT/enhancer-binding protein-homologous protein pathway.
Kim JH, Park B, Gupta SC, Kannappan R, Sung B, Aggarwal BB. Kim JH, et al. Among authors: kannappan r. Antioxid Redox Signal. 2012 Mar 1;16(5):413-27. doi: 10.1089/ars.2011.3982. Epub 2011 Dec 15. Antioxid Redox Signal. 2012. PMID: 22004570 Free PMC article.
NF-κB addiction and its role in cancer: 'one size does not fit all'.
Chaturvedi MM, Sung B, Yadav VR, Kannappan R, Aggarwal BB. Chaturvedi MM, et al. Among authors: kannappan r. Oncogene. 2011 Apr 7;30(14):1615-30. doi: 10.1038/onc.2010.566. Epub 2010 Dec 20. Oncogene. 2011. PMID: 21170083 Free PMC article. Review.
61 results