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Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge.
Gary EN, Tursi NJ, Warner BM, Cuismano G, Connors J, Parzych EM, Griffin BD, Bell MR, Ali AR, Frase D, Hojecki CE, Canziani GA, Chaiken I, Kannan T, Moffat E, Embury-Hyatt C, Wooton SK, Kossenkov A, Patel A, Kobasa D, Kutzler MA, Haddad EK, Weiner DB. Gary EN, et al. Among authors: kannan t. Front Immunol. 2023 Mar 14;14:1138609. doi: 10.3389/fimmu.2023.1138609. eCollection 2023. Front Immunol. 2023. PMID: 36999023 Free PMC article.
The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer.
Mirji G, Worth A, Bhat SA, El Sayed M, Kannan T, Goldman AR, Tang HY, Liu Q, Auslander N, Dang CV, Abdel-Mohsen M, Kossenkov A, Stanger BZ, Shinde RS. Mirji G, et al. Among authors: kannan t. Sci Immunol. 2022 Sep 9;7(75):eabn0704. doi: 10.1126/sciimmunol.abn0704. Epub 2022 Sep 9. Sci Immunol. 2022. PMID: 36083892 Free PMC article.
Common activities and predictive gene signature identified for genetic hypomorphs of TP53.
Leung JC, Leu JI, Indeglia A, Kannan T, Clarke NL, Kirven NA, Dweep H, Garlick D, Barnoud T, Kossenkov AV, George DL, Murphy ME. Leung JC, et al. Among authors: kannan t. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2212940120. doi: 10.1073/pnas.2212940120. Epub 2023 Feb 7. Proc Natl Acad Sci U S A. 2023. PMID: 36749725 Free PMC article.
Engineered antibody cytokine chimera synergizes with DNA-launched nanoparticle vaccines to potentiate melanoma suppression in vivo.
Tursi NJ, Xu Z, Helble M, Walker S, Liaw K, Chokkalingam N, Kannan T, Wu Y, Tello-Ruiz E, Park DH, Zhu X, Wise MC, Smith TRF, Majumdar S, Kossenkov A, Kulp DW, Weiner DB. Tursi NJ, et al. Among authors: kannan t. Front Immunol. 2023 Feb 23;14:1072810. doi: 10.3389/fimmu.2023.1072810. eCollection 2023. Front Immunol. 2023. PMID: 36911698 Free PMC article.
The Natural Stilbenoid (-)-Hopeaphenol Inhibits HIV Transcription by Targeting Both PKC and NF-κB Signaling and Cyclin-Dependent Kinase 9.
Tietjen I, Schonhofer C, Sciorillo A, Naidu ME, Haq Z, Kannan T, Kossenkov AV, Rivera-Ortiz J, Mounzer K, Hart C, Gyampoh K, Yuan Z, Beattie KD, Rali T, Shuda McGuire K, Davis RA, Montaner LJ. Tietjen I, et al. Among authors: kannan t. Antimicrob Agents Chemother. 2023 Apr 18;67(4):e0160022. doi: 10.1128/aac.01600-22. Epub 2023 Mar 15. Antimicrob Agents Chemother. 2023. PMID: 36975214 Free PMC article.
An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.
Indeglia A, Leung JC, Miller SA, Leu JI, Dougherty JF, Clarke NL, Kirven NA, Shao C, Ke L, Lovell S, Barnoud T, Lu DY, Lin C, Kannan T, Battaile KP, Yang THL, Batista Oliva I, Claiborne DT, Vogel P, Liu L, Liu Q, Nefedova Y, Cassel J, Auslander N, Kossenkov AV, Karanicolas J, Murphy ME. Indeglia A, et al. Among authors: kannan t. Cancer Discov. 2023 Jul 7;13(7):1696-1719. doi: 10.1158/2159-8290.CD-22-1315. Cancer Discov. 2023. PMID: 37140445 Free PMC article.
PARP1 Inhibition Halts EBV+ Lymphoma Progression by Disrupting the EBNA2/MYC Axis.
Napoletani G, Soldan SS, Kannan T, Preston-Alp S, Vogel P, Maestri D, Caruso LB, Kossenkov A, Sobotka A, Lieberman PM, Tempera I. Napoletani G, et al. Among authors: kannan t. bioRxiv [Preprint]. 2023 Jul 7:2023.07.05.547847. doi: 10.1101/2023.07.05.547847. bioRxiv. 2023. PMID: 37461649 Free PMC article. Preprint.
Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer.
Miller KD, O'Connor S, Pniewski KA, Kannan T, Acosta R, Mirji G, Papp S, Hulse M, Mukha D, Hlavaty SI, Salcido KN, Bertolazzi F, Srikanth YVV, Zhao S, Wellen KE, Shinde RS, Claiborne DT, Kossenkov A, Salvino JM, Schug ZT. Miller KD, et al. Among authors: kannan t. Nat Cancer. 2023 Oct;4(10):1491-1507. doi: 10.1038/s43018-023-00636-6. Epub 2023 Sep 18. Nat Cancer. 2023. PMID: 37723305
The African natural product knipholone anthrone and its analogue anthralin (dithranol) enhance HIV-1 latency reversal.
Richard K, Schonhofer C, Giron LB, Rivera-Ortiz J, Read S, Kannan T, Kinloch NN, Shahid A, Feilcke R, Wappler S, Imming P, Harris M, Brumme ZL, Brockman MA, Mounzer K, Kossenkov AV, Abdel-Mohsen M, Andrae-Marobela K, Montaner LJ, Tietjen I. Richard K, et al. Among authors: kannan t. J Biol Chem. 2020 Oct 9;295(41):14084-14099. doi: 10.1074/jbc.RA120.013031. Epub 2020 Aug 11. J Biol Chem. 2020. PMID: 32788215 Free PMC article.
223 results