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Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza.
Scott C, Kankanala J, Foster TL, Goldhill DH, Bao P, Simmons K, Pingen M, Bentham M, Atkins E, Loundras E, Elderfield R, Claridge JK, Thompson J, Stilwell PR, Tathineni R, McKimmie CS, Targett-Adams P, Schnell JR, Cook GP, Evans S, Barclay WS, Foster R, Griffin S. Scott C, et al. Among authors: kankanala j. PLoS Pathog. 2020 Aug 11;16(8):e1008716. doi: 10.1371/journal.ppat.1008716. eCollection 2020 Aug. PLoS Pathog. 2020. PMID: 32780760 Free PMC article.
Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release.
Foster TL, Thompson GS, Kalverda AP, Kankanala J, Bentham M, Wetherill LF, Thompson J, Barker AM, Clarke D, Noerenberg M, Pearson AR, Rowlands DJ, Homans SW, Harris M, Foster R, Griffin S. Foster TL, et al. Among authors: kankanala j. Hepatology. 2014 Feb;59(2):408-22. doi: 10.1002/hep.26685. Epub 2013 Dec 24. Hepatology. 2014. PMID: 24022996 Free PMC article.
Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy.
Shaw J, Gosain R, Kalita MM, Foster TL, Kankanala J, Mahato DR, Abas S, King BJ, Scott C, Brown E, Bentham MJ, Wetherill L, Bloy A, Samson A, Harris M, Mankouri J, Rowlands DJ, Macdonald A, Tarr AW, Fischer WB, Foster R, Griffin S. Shaw J, et al. Among authors: kankanala j. Elife. 2020 Nov 10;9:e52555. doi: 10.7554/eLife.52555. Elife. 2020. PMID: 33169665 Free PMC article.
Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity.
Vernekar SKV, Tang J, Wu B, Huber AD, Casey MC, Myshakina N, Wilson DJ, Kankanala J, Kirby KA, Parniak MA, Sarafianos SG, Wang Z. Vernekar SKV, et al. Among authors: kankanala j. J Med Chem. 2017 Jun 22;60(12):5045-5056. doi: 10.1021/acs.jmedchem.7b00440. Epub 2017 May 31. J Med Chem. 2017. PMID: 28525279 Free PMC article.
Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors.
Ribeiro CJA, Kankanala J, Xie J, Williams J, Aihara H, Wang Z. Ribeiro CJA, et al. Among authors: kankanala j. Bioorg Med Chem Lett. 2019 Jan 15;29(2):257-261. doi: 10.1016/j.bmcl.2018.11.044. Epub 2018 Nov 22. Bioorg Med Chem Lett. 2019. PMID: 30522956 Free PMC article.
30 results