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3,637 results

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RAD21 amplification epigenetically suppresses interferon signaling to promote immune evasion in ovarian cancer.
Deng P, Wang Z, Chen J, Liu S, Yao X, Liu S, Liu L, Yu Z, Huang Y, Xiong Z, Xiao R, Gao J, Liang W, Chen J, Liu H, Hong JH, Chan JY, Guan P, Chen J, Wang Y, Yin J, Li J, Zheng M, Zhang C, Zhou P, Kang T, Teh BT, Yu Q, Zuo Z, Jiang Q, Liu J, Xiong Y, Xia X, Tan J. Deng P, et al. Among authors: kang t. J Clin Invest. 2022 Nov 15;132(22):e159628. doi: 10.1172/JCI159628. J Clin Invest. 2022. PMID: 36201246 Free PMC article.
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells.
Song LB, Li J, Liao WT, Feng Y, Yu CP, Hu LJ, Kong QL, Xu LH, Zhang X, Liu WL, Li MZ, Zhang L, Kang TB, Fu LW, Huang WL, Xia YF, Tsao SW, Li M, Band V, Band H, Shi QH, Zeng YX, Zeng MS. Song LB, et al. J Clin Invest. 2009 Dec;119(12):3626-36. doi: 10.1172/JCI39374. Epub 2009 Nov 2. J Clin Invest. 2009. PMID: 19884659 Free PMC article.
Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis.
Li XJ, Ong CK, Cao Y, Xiang YQ, Shao JY, Ooi A, Peng LX, Lu WH, Zhang Z, Petillo D, Qin L, Bao YN, Zheng FJ, Chia CS, Iyer NG, Kang TB, Zeng YX, Soo KC, Trent JM, Teh BT, Qian CN. Li XJ, et al. Cancer Res. 2011 Apr 15;71(8):3162-72. doi: 10.1158/0008-5472.CAN-10-3557. Epub 2011 Feb 2. Cancer Res. 2011. PMID: 21289131
CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma.
Hong J, Hu K, Yuan Y, Sang Y, Bu Q, Chen G, Yang L, Li B, Huang P, Chen D, Liang Y, Zhang R, Pan J, Zeng YX, Kang T. Hong J, et al. Among authors: kang t. J Clin Invest. 2012 Jun;122(6):2165-75. doi: 10.1172/JCI61380. Epub 2012 May 15. J Clin Invest. 2012. PMID: 22585575 Free PMC article. Clinical Trial.
As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling.
Li XJ, Peng LX, Shao JY, Lu WH, Zhang JX, Chen S, Chen ZY, Xiang YQ, Bao YN, Zheng FJ, Zeng MS, Kang TB, Zeng YX, Teh BT, Qian CN. Li XJ, et al. Carcinogenesis. 2012 Jul;33(7):1302-9. doi: 10.1093/carcin/bgs181. Epub 2012 May 18. Carcinogenesis. 2012. PMID: 22610073 Free PMC article.
CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia.
Wang J, Chen S, Xiao W, Li W, Wang L, Yang S, Wang W, Xu L, Liao S, Liu W, Wang Y, Liu N, Zhang J, Xia X, Kang T, Chen G, Cai X, Yang H, Zhang X, Lu Y, Zhou P. Wang J, et al. Among authors: kang t. J Hematol Oncol. 2018 Jan 10;11(1):7. doi: 10.1186/s13045-017-0553-5. J Hematol Oncol. 2018. PMID: 29316944 Free PMC article.
Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma.
You R, Liu YP, Lin DC, Li Q, Yu T, Zou X, Lin M, Zhang XL, He GP, Yang Q, Zhang YN, Xie YL, Jiang R, Wu CY, Zhang C, Cui C, Wang JQ, Wang Y, Zhuang AH, Guo GF, Hua YJ, Sun R, Yun JP, Zuo ZX, Liu ZX, Zhu XF, Kang TB, Qian CN, Mai HQ, Sun Y, Zeng MS, Feng L, Zeng YX, Chen MY. You R, et al. Among authors: kang tb. Cancer Res. 2019 Dec 1;79(23):5930-5943. doi: 10.1158/0008-5472.CAN-18-3845. Epub 2019 Sep 4. Cancer Res. 2019. PMID: 31484669
DGKA Mediates Resistance to PD-1 Blockade.
Fu L, Li S, Xiao W, Yu K, Li S, Yuan S, Shen J, Dong X, Fang Z, Zhang J, Chen S, Li W, You H, Xia X, Kang T, Tan J, Chen G, Yang AK, Gao Y, Zhou P. Fu L, et al. Among authors: kang t. Cancer Immunol Res. 2021 Apr;9(4):371-385. doi: 10.1158/2326-6066.CIR-20-0216. Epub 2021 Feb 19. Cancer Immunol Res. 2021. PMID: 33608256
Targeting enhancer reprogramming to mitigate MEK inhibitor resistance in preclinical models of advanced ovarian cancer.
Liu S, Zou Q, Chen JP, Yao X, Guan P, Liang W, Deng P, Lai X, Yin J, Chen J, Chen R, Yu Z, Xiao R, Sun Y, Hong JH, Liu H, Lu H, Chen J, Bei JX, Koh J, Chan JY, Wang B, Kang T, Yu Q, Teh BT, Liu J, Xiong Y, Tan J. Liu S, et al. Among authors: kang t. J Clin Invest. 2021 Oct 15;131(20):e145035. doi: 10.1172/JCI145035. J Clin Invest. 2021. PMID: 34464356 Free PMC article.
3,637 results