Kang SA - Search Results

1

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM. Peterson TR, et al. Among authors: kang sa. Cell. 2011 Aug 5;146(3):408-20. doi: 10.1016/j.cell.2011.06.034. Cell. 2011. PMID: 21816276 Free PMC article.

2

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM. Sancak Y, et al. Among authors: kang sa. Mol Cell. 2007 Mar 23;25(6):903-15. doi: 10.1016/j.molcel.2007.03.003. Mol Cell. 2007. PMID: 17386266 Free article.

3

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.

Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM. Peterson TR, et al. Among authors: kang sa. Cell. 2009 May 29;137(5):873-86. doi: 10.1016/j.cell.2009.03.046. Epub 2009 May 14. Cell. 2009. PMID: 19446321 Free PMC article.

4

Structure of the human mTOR complex I and its implications for rapamycin inhibition.

Yip CK, Murata K, Walz T, Sabatini DM, Kang SA. Yip CK, et al. Among authors: kang sa. Mol Cell. 2010 Jun 11;38(5):768-74. doi: 10.1016/j.molcel.2010.05.017. Mol Cell. 2010. PMID: 20542007 Free PMC article.

5

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yaffe MB, Marto JA, Sabatini DM. Hsu PP, et al. Among authors: kang sa. Science. 2011 Jun 10;332(6035):1317-22. doi: 10.1126/science.1199498. Science. 2011. PMID: 21659604 Free PMC article.

6

Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program.

Kikani CK, Wu X, Fogarty S, Kang SAW, Dephoure N, Gygi SP, Sabatini DM, Rutter J. Kikani CK, et al. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10382-10391. doi: 10.1073/pnas.1804013116. Epub 2019 May 9. Proc Natl Acad Sci U S A. 2019. PMID: 31072927 Free PMC article.

7

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS. Thoreen CC, et al. Among authors: kang sa. J Biol Chem. 2009 Mar 20;284(12):8023-32. doi: 10.1074/jbc.M900301200. Epub 2009 Jan 15. J Biol Chem. 2009. PMID: 19150980 Free PMC article.

8

Development of ATP-competitive mTOR inhibitors.

Liu Q, Kang SA, Thoreen CC, Hur W, Wang J, Chang JW, Markhard A, Zhang J, Sim T, Sabatini DM, Gray NS. Liu Q, et al. Among authors: kang sa. Methods Mol Biol. 2012;821:447-60. doi: 10.1007/978-1-61779-430-8_29. Methods Mol Biol. 2012. PMID: 22125084 Free PMC article.

9

mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin.

Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM. Kang SA, et al. Science. 2013 Jul 26;341(6144):1236566. doi: 10.1126/science.1236566. Science. 2013. PMID: 23888043 Free PMC article.

10

Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters.

Kang SA, O'Neill DJ, Machl AW, Lumpkin CJ, Galda SN, Sengupta S, Mahoney SJ, Howell JJ, Molz L, Hahm S, Vlasuk GP, Saiah E. Kang SA, et al. Cell Chem Biol. 2019 Sep 19;26(9):1203-1213.e13. doi: 10.1016/j.chembiol.2019.05.009. Epub 2019 Jun 20. Cell Chem Biol. 2019. PMID: 31231029 Free article.

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