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Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload.
Ge C, Huang H, Huang F, Yang T, Zhang T, Wu H, Zhou H, Chen Q, Shi Y, Sun Y, Liu L, Wang X, Pearson RB, Cao Y, Kang J, Fu C. Ge C, et al. Among authors: kang j. Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19635-19645. doi: 10.1073/pnas.1908998116. Epub 2019 Sep 5. Proc Natl Acad Sci U S A. 2019. PMID: 31488714 Free PMC article.
Cystathionine β-Synthase in Physiology and Cancer.
Zhu H, Blake S, Chan KT, Pearson RB, Kang J. Zhu H, et al. Among authors: kang j. Biomed Res Int. 2018 Jun 28;2018:3205125. doi: 10.1155/2018/3205125. eCollection 2018. Biomed Res Int. 2018. PMID: 30050925 Free PMC article. Review.
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.
Sanij E, Hannan KM, Xuan J, Yan S, Ahern JE, Trigos AS, Brajanovski N, Son J, Chan KT, Kondrashova O, Lieschke E, Wakefield MJ, Frank D, Ellis S, Cullinane C, Kang J, Poortinga G, Nag P, Deans AJ, Khanna KK, Mileshkin L, McArthur GA, Soong J, Berns EMJJ, Hannan RD, Scott CL, Sheppard KE, Pearson RB. Sanij E, et al. Among authors: kang j. Nat Commun. 2020 May 26;11(1):2641. doi: 10.1038/s41467-020-16393-4. Nat Commun. 2020. PMID: 32457376 Free PMC article.
Targeting the ribosome to treat multiple myeloma.
Maclachlan KH, Gitareja K, Kang J, Cuddihy A, Cao Y, Hein N, Cullinane C, Ang CS, Brajanovski N, Pearson RB, Khot A, Sanij E, Hannan RD, Poortinga G, Harrison SJ. Maclachlan KH, et al. Among authors: kang j. Mol Ther Oncol. 2024 Feb 7;32(1):200771. doi: 10.1016/j.omton.2024.200771. eCollection 2024 Mar 21. Mol Ther Oncol. 2024. PMID: 38596309 Free PMC article.
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