Kanepe-Lapsa I - Search Results

1

Selenium analogues of raloxifene as promising antiproliferative agents in treatment of breast cancer.

Arsenyan P, Paegle E, Domracheva I, Gulbe A, Kanepe-Lapsa I, Shestakova I. Arsenyan P, et al. Eur J Med Chem. 2014 Nov 24;87:471-83. doi: 10.1016/j.ejmech.2014.09.088. Epub 2014 Sep 30. Eur J Med Chem. 2014. PMID: 25282270

2

Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV.

Rasina D, Otikovs M, Leitans J, Recacha R, Borysov OV, Kanepe-Lapsa I, Domraceva I, Pantelejevs T, Tars K, Blackman MJ, Jaudzems K, Jirgensons A. Rasina D, et al. Among authors: kanepe lapsa i. J Med Chem. 2016 Jan 14;59(1):374-87. doi: 10.1021/acs.jmedchem.5b01558. Epub 2015 Dec 23. J Med Chem. 2016. PMID: 26670264

3

Natural-Antioxidant-Inspired Benzo[b]selenophenes: Synthesis, Redox Properties, and Antiproliferative Activity.

Paegle E, Domracheva I, Turovska B, Petrova M, Kanepe-Lapsa I, Gulbe A, Liepinsh E, Arsenyan P. Paegle E, et al. Among authors: kanepe lapsa i. Chem Asian J. 2016 Jul 5;11(13):1929-38. doi: 10.1002/asia.201600472. Epub 2016 Jun 7. Chem Asian J. 2016. PMID: 27146245

4

Selenopheno quinolinones and coumarins promote cancer cell apoptosis by ROS depletion and caspase-7 activation.

Domracheva I, Kanepe-Lapsa I, Jackevica L, Vasiljeva J, Arsenyan P. Domracheva I, et al. Among authors: kanepe lapsa i. Life Sci. 2017 Oct 1;186:92-101. doi: 10.1016/j.lfs.2017.08.011. Epub 2017 Aug 12. Life Sci. 2017. PMID: 28807721

5

Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D.

Zogota R, Kinena L, Withers-Martinez C, Blackman MJ, Bobrovs R, Pantelejevs T, Kanepe-Lapsa I, Ozola V, Jaudzems K, Suna E, Jirgensons A. Zogota R, et al. Among authors: kanepe lapsa i. Eur J Med Chem. 2019 Feb 1;163:344-352. doi: 10.1016/j.ejmech.2018.11.068. Epub 2018 Nov 29. Eur J Med Chem. 2019. PMID: 30529637 Free PMC article.

6

4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action.

Domracheva I, Kanepe-Lapsa I, Vilskersts R, Bruvere I, Bisenieks E, Velena A, Turovska B, Duburs G. Domracheva I, et al. Among authors: kanepe lapsa i. Oxid Med Cell Longev. 2020 Mar 27;2020:2075815. doi: 10.1155/2020/2075815. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 32308799 Free PMC article.

7

Aromatic sulphonamides of aziridine-2-carboxylic acid derivatives as novel PDIA1 and PDIA3 inhibitors.

Zelencova-Gopejenko D, Andrianov V, Domracheva I, Kanepe-Lapsa I, Milczarek M, Stojak M, Przyborowski K, Fedak FA, Walczak M, Kramkowski K, Wietrzyk J, Chlopicki S, Kalvins I. Zelencova-Gopejenko D, et al. Among authors: kanepe lapsa i. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2158187. doi: 10.1080/14756366.2022.2158187. J Enzyme Inhib Med Chem. 2023. PMID: 37070480 Free PMC article.

8

Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit.

Jaudzems K, Tars K, Maurops G, Ivdra N, Otikovs M, Leitans J, Kanepe-Lapsa I, Domraceva I, Mutule I, Trapencieris P, Blackman MJ, Jirgensons A. Jaudzems K, et al. ACS Med Chem Lett. 2014 Jan 13;5(4):373-7. doi: 10.1021/ml4004952. eCollection 2014 Apr 10. ACS Med Chem Lett. 2014. PMID: 24900843 Free PMC article.

9

2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity.

Rasina D, Stakanovs G, Borysov OV, Pantelejevs T, Bobrovs R, Kanepe-Lapsa I, Tars K, Jaudzems K, Jirgensons A. Rasina D, et al. Among authors: kanepe lapsa i. Bioorg Med Chem. 2018 May 15;26(9):2488-2500. doi: 10.1016/j.bmc.2018.04.012. Epub 2018 Apr 5. Bioorg Med Chem. 2018. PMID: 29636223

10

Azole-based non-peptidomimetic plasmepsin inhibitors.

Kinena L, Leitis G, Kanepe-Lapsa I, Bobrovs R, Jaudzems K, Ozola V, Suna E, Jirgensons A. Kinena L, et al. Among authors: kanepe lapsa i. Arch Pharm (Weinheim). 2018 Sep;351(9):e1800151. doi: 10.1002/ardp.201800151. Epub 2018 Jul 31. Arch Pharm (Weinheim). 2018. PMID: 30063266

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