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Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.
Bruchard M, Mignot G, Derangère V, Chalmin F, Chevriaux A, Végran F, Boireau W, Simon B, Ryffel B, Connat JL, Kanellopoulos J, Martin F, Rébé C, Apetoh L, Ghiringhelli F. Bruchard M, et al. Among authors: kanellopoulos j. Nat Med. 2013 Jan;19(1):57-64. doi: 10.1038/nm.2999. Epub 2012 Dec 2. Nat Med. 2013. PMID: 23202296
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Génin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, André F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L. Ghiringhelli F, et al. Among authors: kanellopoulos j. Nat Med. 2009 Oct;15(10):1170-8. doi: 10.1038/nm.2028. Epub 2009 Sep 20. Nat Med. 2009. PMID: 19767732
A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy.
Douguet L, Janho Dit Hreich S, Benzaquen J, Seguin L, Juhel T, Dezitter X, Duranton C, Ryffel B, Kanellopoulos J, Delarasse C, Renault N, Furman C, Homerin G, Féral C, Cherfils-Vicini J, Millet R, Adriouch S, Ghinet A, Hofman P, Vouret-Craviari V. Douguet L, et al. Among authors: kanellopoulos j. Nat Commun. 2021 Jan 28;12(1):653. doi: 10.1038/s41467-021-20912-2. Nat Commun. 2021. PMID: 33510147 Free PMC article.
Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection.
Séror C, Melki MT, Subra F, Raza SQ, Bras M, Saïdi H, Nardacci R, Voisin L, Paoletti A, Law F, Martins I, Amendola A, Abdul-Sater AA, Ciccosanti F, Delelis O, Niedergang F, Thierry S, Said-Sadier N, Lamaze C, Métivier D, Estaquier J, Fimia GM, Falasca L, Casetti R, Modjtahedi N, Kanellopoulos J, Mouscadet JF, Ojcius DM, Piacentini M, Gougeon ML, Kroemer G, Perfettini JL. Séror C, et al. Among authors: kanellopoulos j. J Exp Med. 2011 Aug 29;208(9):1823-34. doi: 10.1084/jem.20101805. Epub 2011 Aug 22. J Exp Med. 2011. PMID: 21859844 Free PMC article.
Is the inflammasome relevant for epithelial cell function?
Santana PT, Martel J, Lai HC, Perfettini JL, Kanellopoulos JM, Young JD, Coutinho-Silva R, Ojcius DM. Santana PT, et al. Among authors: kanellopoulos jm. Microbes Infect. 2016 Feb;18(2):93-101. doi: 10.1016/j.micinf.2015.10.007. Epub 2015 Nov 10. Microbes Infect. 2016. PMID: 26546965 Free article. Review.
New role of P2X7 receptor in an Alzheimer's disease mouse model.
Martin E, Amar M, Dalle C, Youssef I, Boucher C, Le Duigou C, Brückner M, Prigent A, Sazdovitch V, Halle A, Kanellopoulos JM, Fontaine B, Delatour B, Delarasse C. Martin E, et al. Mol Psychiatry. 2019 Jan;24(1):108-125. doi: 10.1038/s41380-018-0108-3. Epub 2018 Jun 22. Mol Psychiatry. 2019. PMID: 29934546 Free PMC article.
105 results