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Metabolic alterations precede neurofilament changes in presymptomatic ALS gene carriers.
Dorst J, Weydt P, Brenner D, Witzel S, Kandler K, Huss A, Herrmann C, Wiesenfarth M, Knehr A, Günther K, Müller K, Weishaupt JH, Prudlo J, Forsberg K, Andersen PM, Rosenbohm A, Schuster J, Roselli F, Dupuis L, Mayer B, Tumani H, Kassubek J, Ludolph AC. Dorst J, et al. Among authors: kandler k. EBioMedicine. 2023 Apr;90:104521. doi: 10.1016/j.ebiom.2023.104521. Epub 2023 Mar 12. EBioMedicine. 2023. PMID: 36917918 Free PMC article.
Phenotyping of the thoracic-onset variant of amyotrophic lateral sclerosis.
Kandler K, Witzel S, Eder K, Rothenbacher D, Nagel G, Peter RS, Schuster J, Dorst J, Rosenbohm A, Ludolph AC; ALS Registry Study Group. Kandler K, et al. J Neurol Neurosurg Psychiatry. 2022 May;93(5):563-565. doi: 10.1136/jnnp-2021-326712. Epub 2021 Oct 19. J Neurol Neurosurg Psychiatry. 2022. PMID: 34667101 No abstract available.
Fat-rich versus carbohydrate-rich nutrition in ALS: a randomised controlled study.
Dorst J, Doenz J, Kandler K, Dreyhaupt J, Tumani H, Witzel S, Schuster J, Ludolph AC. Dorst J, et al. Among authors: kandler k. J Neurol Neurosurg Psychiatry. 2022 Mar;93(3):298-302. doi: 10.1136/jnnp-2021-328331. Epub 2022 Jan 12. J Neurol Neurosurg Psychiatry. 2022. PMID: 35022317 Clinical Trial.
Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS.
Miller TM, Cudkowicz ME, Genge A, Shaw PJ, Sobue G, Bucelli RC, Chiò A, Van Damme P, Ludolph AC, Glass JD, Andrews JA, Babu S, Benatar M, McDermott CJ, Cochrane T, Chary S, Chew S, Zhu H, Wu F, Nestorov I, Graham D, Sun P, McNeill M, Fanning L, Ferguson TA, Fradette S; VALOR and OLE Working Group. Miller TM, et al. N Engl J Med. 2022 Sep 22;387(12):1099-1110. doi: 10.1056/NEJMoa2204705. N Engl J Med. 2022. PMID: 36129998 Free article. Clinical Trial.
ALS is imprinted in the chromatin accessibility of blood cells.
Kühlwein JK, Ruf WP, Kandler K, Witzel S, Lang C, Mulaw MA, Ekici AB, Weishaupt JH, Ludolph AC, Grozdanov V, Danzer KM. Kühlwein JK, et al. Among authors: kandler k. Cell Mol Life Sci. 2023 Apr 24;80(5):131. doi: 10.1007/s00018-023-04769-w. Cell Mol Life Sci. 2023. PMID: 37095391 Free PMC article.
Low T-cell reactivity to TDP-43 peptides in ALS.
Ramachandran S, Grozdanov V, Leins B, Kandler K, Witzel S, Mulaw M, Ludolph AC, Weishaupt JH, Danzer KM. Ramachandran S, et al. Among authors: kandler k. Front Immunol. 2023 Jul 21;14:1193507. doi: 10.3389/fimmu.2023.1193507. eCollection 2023. Front Immunol. 2023. PMID: 37545536 Free PMC article.
A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS): the statistical analysis plan of TUDCA-ALS trial.
Lombardo FL, Spila Alegiani S, Mayer F, Cipriani M, Lo Giudice M, Ludolph AC, McDermott CJ, Corcia P, Van Damme P, Van den Berg LH, Hardiman O, Nicolini G, Vanacore N, Dickie B, Albanese A, Puopolo M; TUDCA-ALS Study Group. Lombardo FL, et al. Trials. 2023 Dec 5;24(1):792. doi: 10.1186/s13063-023-07638-w. Trials. 2023. PMID: 38053196 Free PMC article. Clinical Trial.
Effects of tofersen treatment in patients with SOD1-ALS in a "real-world" setting - a 12-month multicenter cohort study from the German early access program.
Wiesenfarth M, Dorst J, Brenner D, Elmas Z, Parlak Ö, Uzelac Z, Kandler K, Mayer K, Weiland U, Herrmann C, Schuster J, Freischmidt A, Müller K, Siebert R, Bachhuber F, Simak T, Günther K, Fröhlich E, Knehr A, Regensburger M, German A, Petri S, Grosskreutz J, Klopstock T, Reilich P, Schöberl F, Hagenacker T, Weyen U, Günther R, Vidovic M, Jentsch M, Haarmeier T, Weydt P, Valkadinov I, Hesebeck-Brinckmann J, Conrad J, Weishaupt JH, Schumann P, Körtvélyessy P, Meyer T, Ruf WP, Witzel S, Senel M, Tumani H, Ludolph AC. Wiesenfarth M, et al. Among authors: kandler k. EClinicalMedicine. 2024 Feb 15;69:102495. doi: 10.1016/j.eclinm.2024.102495. eCollection 2024 Mar. EClinicalMedicine. 2024. PMID: 38384337 Free PMC article.
97 results