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Dietary modifications for enhanced cancer therapy.
Kanarek N, Petrova B, Sabatini DM. Kanarek N, et al. Nature. 2020 Mar;579(7800):507-517. doi: 10.1038/s41586-020-2124-0. Epub 2020 Mar 25. Nature. 2020. PMID: 32214253 Review.
The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase.
Heppler LN, Attarha S, Persaud R, Brown JI, Wang P, Petrova B, Tošić I, Burton FB, Flamand Y, Walker SR, Yeh JE, Zubarev RA, Gaetani M, Kanarek N, Page BDG, Frank DA. Heppler LN, et al. Among authors: kanarek n. J Biol Chem. 2022 Feb;298(2):101531. doi: 10.1016/j.jbc.2021.101531. Epub 2021 Dec 23. J Biol Chem. 2022. PMID: 34953855 Free PMC article.
Copper induces cell death by targeting lipoylated TCA cycle proteins.
Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR. Tsvetkov P, et al. Among authors: kanarek n. Science. 2022 Mar 18;375(6586):1254-1261. doi: 10.1126/science.abf0529. Epub 2022 Mar 17. Science. 2022. PMID: 35298263 Free PMC article.
FDX1 regulates cellular protein lipoylation through direct binding to LIAS.
Dreishpoon MB, Bick NR, Petrova B, Warui DM, Cameron A, Booker SJ, Kanarek N, Golub TR, Tsvetkov P. Dreishpoon MB, et al. Among authors: kanarek n. bioRxiv [Preprint]. 2023 Feb 4:2023.02.03.526472. doi: 10.1101/2023.02.03.526472. bioRxiv. 2023. PMID: 36778498 Free PMC article. Updated. Preprint.
Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity.
Brown JI, Wang P, Wong AYL, Petrova B, Persaud R, Soukhtehzari S, Lopez McDonald M, Hanke D, Christensen J, Iliev P, Wang W, Everton DK, Williams KC, Frank DA, Kanarek N, Page BDG. Brown JI, et al. Among authors: kanarek n. Metabolites. 2023 Jan 19;13(2):151. doi: 10.3390/metabo13020151. Metabolites. 2023. PMID: 36837770 Free PMC article.
108 results