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Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines.
Kamata M, Yamashita T, Imaeda T, Tanaka T, Masada S, Kamaura M, Kasai S, Hara R, Sasaki S, Takekawa S, Asami A, Kaisho T, Suzuki N, Ashina S, Ogino H, Nakano Y, Nagisa Y, Kato K, Kato K, Ishihara Y. Kamata M, et al. J Med Chem. 2012 Mar 8;55(5):2353-66. doi: 10.1021/jm201596h. Epub 2012 Feb 22. J Med Chem. 2012. PMID: 22309223
Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists.
Kamata M, Yamashita T, Imaeda T, Tanaka T, Terauchi J, Miyamoto M, Ora T, Tawada M, Endo S, Takekawa S, Asami A, Suzuki N, Nagisa Y, Nakano Y, Watanabe K, Ogino H, Kato K, Kato K, Ishihara Y. Kamata M, et al. Bioorg Med Chem. 2011 Sep 15;19(18):5539-52. doi: 10.1016/j.bmc.2011.07.038. Epub 2011 Jul 26. Bioorg Med Chem. 2011. PMID: 21856163
Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives.
Kasai S, Kamaura M, Kamata M, Aso K, Ogino H, Nakano Y, Watanabe K, Kaisho T, Tawada M, Nagisa Y, Takekawa S, Kato K, Suzuki N, Ishihara Y. Kasai S, et al. Among authors: kamata m. Bioorg Med Chem. 2011 Nov 1;19(21):6261-73. doi: 10.1016/j.bmc.2011.09.007. Epub 2011 Sep 10. Bioorg Med Chem. 2011. PMID: 21975069
Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities.
Kasai S, Kamata M, Masada S, Kunitomo J, Kamaura M, Okawa T, Takami K, Ogino H, Nakano Y, Ashina S, Watanabe K, Kaisho T, Imai YN, Ryu S, Nakayama M, Nagisa Y, Takekawa S, Kato K, Murata T, Suzuki N, Ishihara Y. Kasai S, et al. Among authors: kamata m. J Med Chem. 2012 May 10;55(9):4336-51. doi: 10.1021/jm300167z. Epub 2012 Apr 23. J Med Chem. 2012. PMID: 22490048
Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes.
Banno Y, Sasaki S, Kamata M, Kunitomo J, Miyamoto Y, Abe H, Taya N, Oi S, Watanabe M, Urushibara T, Hazama M, Niwa SI, Miyamoto S, Horinouchi A, Kuroshima KI, Amano N, Matsumoto SI, Matsunaga S. Banno Y, et al. Among authors: kamata m. Bioorg Med Chem. 2017 Nov 1;25(21):5995-6006. doi: 10.1016/j.bmc.2017.09.031. Epub 2017 Sep 21. Bioorg Med Chem. 2017. PMID: 28988629
Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.
Yamashita T, Kamata M, Endo S, Yamamoto M, Kakegawa K, Watanabe H, Miwa K, Yamano T, Funata M, Sakamoto J, Tani A, Mol CD, Zou H, Dougan DR, Sang B, Snell G, Fukatsu K. Yamashita T, et al. Among authors: kamata m. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8. doi: 10.1016/j.bmcl.2011.08.117. Epub 2011 Sep 6. Bioorg Med Chem Lett. 2011. PMID: 21944854
465 results