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Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments.
Kumagai S, Koyama S, Itahashi K, Tanegashima T, Lin YT, Togashi Y, Kamada T, Irie T, Okumura G, Kono H, Ito D, Fujii R, Watanabe S, Sai A, Fukuoka S, Sugiyama E, Watanabe G, Owari T, Nishinakamura H, Sugiyama D, Maeda Y, Kawazoe A, Yukami H, Chida K, Ohara Y, Yoshida T, Shinno Y, Takeyasu Y, Shirasawa M, Nakama K, Aokage K, Suzuki J, Ishii G, Kuwata T, Sakamoto N, Kawazu M, Ueno T, Mori T, Yamazaki N, Tsuboi M, Yatabe Y, Kinoshita T, Doi T, Shitara K, Mano H, Nishikawa H. Kumagai S, et al. Among authors: kamada t. Cancer Cell. 2022 Feb 14;40(2):201-218.e9. doi: 10.1016/j.ccell.2022.01.001. Epub 2022 Jan 28. Cancer Cell. 2022. PMID: 35090594 Free article.
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer.
Kamada T, Togashi Y, Tay C, Ha D, Sasaki A, Nakamura Y, Sato E, Fukuoka S, Tada Y, Tanaka A, Morikawa H, Kawazoe A, Kinoshita T, Shitara K, Sakaguchi S, Nishikawa H. Kamada T, et al. Proc Natl Acad Sci U S A. 2019 May 14;116(20):9999-10008. doi: 10.1073/pnas.1822001116. Epub 2019 Apr 26. Proc Natl Acad Sci U S A. 2019. PMID: 31028147 Free PMC article.
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies.
Kumagai S, Togashi Y, Kamada T, Sugiyama E, Nishinakamura H, Takeuchi Y, Vitaly K, Itahashi K, Maeda Y, Matsui S, Shibahara T, Yamashita Y, Irie T, Tsuge A, Fukuoka S, Kawazoe A, Udagawa H, Kirita K, Aokage K, Ishii G, Kuwata T, Nakama K, Kawazu M, Ueno T, Yamazaki N, Goto K, Tsuboi M, Mano H, Doi T, Shitara K, Nishikawa H. Kumagai S, et al. Among authors: kamada t. Nat Immunol. 2020 Nov;21(11):1346-1358. doi: 10.1038/s41590-020-0769-3. Epub 2020 Aug 31. Nat Immunol. 2020. PMID: 32868929
Potentiality of multiple modalities for single-cell analyses to evaluate the tumor microenvironment in clinical specimens.
Kashima Y, Togashi Y, Fukuoka S, Kamada T, Irie T, Suzuki A, Nakamura Y, Shitara K, Minamide T, Yoshida T, Taoka N, Kawase T, Wada T, Inaki K, Chihara M, Ebisuno Y, Tsukamoto S, Fujii R, Ohashi A, Suzuki Y, Tsuchihara K, Nishikawa H, Doi T. Kashima Y, et al. Among authors: kamada t. Sci Rep. 2021 Jan 11;11(1):341. doi: 10.1038/s41598-020-79385-w. Sci Rep. 2021. PMID: 33431933 Free PMC article.
Different Food Preferences in Patients with Gastrointestinal Disorders.
Katsumata R, Kaburagi T, Hosokawa T, Manabe N, Ishii M, Ishii K, Tanikawa T, Urata N, Ayaki M, Nishino K, Murao T, Suehiro M, Fujita M, Kawanaka M, Haruma K, Kawamoto H, Takao T, Kamada T. Katsumata R, et al. Among authors: kamada t. Intern Med. 2024 Apr 9. doi: 10.2169/internalmedicine.3433-24. Online ahead of print. Intern Med. 2024. PMID: 38599865 Free article.
A Study of the Risk Factors for 402 Patients with Esophageal Squamous Cell Carcinoma - A Retrospective Comparison with Health Checkup Participants.
Nakamura J, Haruma K, Manabe N, Yamatsuji T, Fujiwara Y, Murao T, Fujita M, Shiotani A, Suehiro M, Kawamoto H, Haisa M, Ueno T, Kamada T, Takao T, Monobe Y, Akiyama T, Naomoto Y, Hata J. Nakamura J, et al. Among authors: kamada t. Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.2950-23. Online ahead of print. Intern Med. 2024. PMID: 38569909 Free article.
1,596 results