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B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models.
Huang D, Abbott RK, Havenar-Daughton C, Skog PD, Al-Kolla R, Groschel B, Blane TR, Menis S, Tran JT, Thinnes TC, Volpi SA, Liguori A, Schiffner T, Villegas SM, Kalyuzhniy O, Pintea M, Voss JE, Phelps N, Tingle R, Rodriguez AR, Martin G, Kupryianov S, deCamp A, Schief WR, Nemazee D, Crotty S. Huang D, et al. Among authors: kalyuzhniy o. Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22920-22931. doi: 10.1073/pnas.2004489117. Epub 2020 Sep 1. Proc Natl Acad Sci U S A. 2020. PMID: 32873644 Free PMC article.
Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope.
Correia BE, Ban YE, Holmes MA, Xu H, Ellingson K, Kraft Z, Carrico C, Boni E, Sather DN, Zenobia C, Burke KY, Bradley-Hewitt T, Bruhn-Johannsen JF, Kalyuzhniy O, Baker D, Strong RK, Stamatatos L, Schief WR. Correia BE, et al. Among authors: kalyuzhniy o. Structure. 2010 Sep 8;18(9):1116-26. doi: 10.1016/j.str.2010.06.010. Structure. 2010. PMID: 20826338 Free article.
Rational HIV immunogen design to target specific germline B cell receptors.
Jardine J, Julien JP, Menis S, Ota T, Kalyuzhniy O, McGuire A, Sok D, Huang PS, MacPherson S, Jones M, Nieusma T, Mathison J, Baker D, Ward AB, Burton DR, Stamatatos L, Nemazee D, Wilson IA, Schief WR. Jardine J, et al. Among authors: kalyuzhniy o. Science. 2013 May 10;340(6133):711-6. doi: 10.1126/science.1234150. Epub 2013 Mar 28. Science. 2013. PMID: 23539181 Free PMC article.
Proof of principle for epitope-focused vaccine design.
Correia BE, Bates JT, Loomis RJ, Baneyx G, Carrico C, Jardine JG, Rupert P, Correnti C, Kalyuzhniy O, Vittal V, Connell MJ, Stevens E, Schroeter A, Chen M, Macpherson S, Serra AM, Adachi Y, Holmes MA, Li Y, Klevit RE, Graham BS, Wyatt RT, Baker D, Strong RK, Crowe JE Jr, Johnson PR, Schief WR. Correia BE, et al. Among authors: kalyuzhniy o. Nature. 2014 Mar 13;507(7491):201-6. doi: 10.1038/nature12966. Epub 2014 Feb 5. Nature. 2014. PMID: 24499818 Free PMC article.
HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.
Jardine JG, Ota T, Sok D, Pauthner M, Kulp DW, Kalyuzhniy O, Skog PD, Thinnes TC, Bhullar D, Briney B, Menis S, Jones M, Kubitz M, Spencer S, Adachi Y, Burton DR, Schief WR, Nemazee D. Jardine JG, et al. Among authors: kalyuzhniy o. Science. 2015 Jul 10;349(6244):156-61. doi: 10.1126/science.aac5894. Epub 2015 Jun 18. Science. 2015. PMID: 26089355 Free PMC article.
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
Jardine JG, Kulp DW, Havenar-Daughton C, Sarkar A, Briney B, Sok D, Sesterhenn F, Ereño-Orbea J, Kalyuzhniy O, Deresa I, Hu X, Spencer S, Jones M, Georgeson E, Adachi Y, Kubitz M, deCamp AC, Julien JP, Wilson IA, Burton DR, Crotty S, Schief WR. Jardine JG, et al. Among authors: kalyuzhniy o. Science. 2016 Mar 25;351(6280):1458-63. doi: 10.1126/science.aad9195. Science. 2016. PMID: 27013733 Free PMC article.
Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.
Jardine JG, Sok D, Julien JP, Briney B, Sarkar A, Liang CH, Scherer EA, Henry Dunand CJ, Adachi Y, Diwanji D, Hsueh J, Jones M, Kalyuzhniy O, Kubitz M, Spencer S, Pauthner M, Saye-Francisco KL, Sesterhenn F, Wilson PC, Galloway DM, Stanfield RL, Wilson IA, Burton DR, Schief WR. Jardine JG, et al. Among authors: kalyuzhniy o. PLoS Pathog. 2016 Aug 25;12(8):e1005815. doi: 10.1371/journal.ppat.1005815. eCollection 2016 Aug. PLoS Pathog. 2016. PMID: 27560183 Free PMC article.
Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice.
Sok D, Briney B, Jardine JG, Kulp DW, Menis S, Pauthner M, Wood A, Lee EC, Le KM, Jones M, Ramos A, Kalyuzhniy O, Adachi Y, Kubitz M, MacPherson S, Bradley A, Friedrich GA, Schief WR, Burton DR. Sok D, et al. Among authors: kalyuzhniy o. Science. 2016 Sep 30;353(6307):1557-1560. doi: 10.1126/science.aah3945. Epub 2016 Sep 8. Science. 2016. PMID: 27608668 Free PMC article.
46 results