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Page 1
Fluorescent retinoid X receptor ligands for fluorescence polarization assay.
Yamada S, Ohsawa F, Fujii S, Shinozaki R, Makishima M, Naitou H, Enomoto S, Tai A, Kakuta H. Yamada S, et al. Among authors: kakuta h. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5143-6. doi: 10.1016/j.bmcl.2010.07.011. Epub 2010 Jul 8. Bioorg Med Chem Lett. 2010. PMID: 20667726
Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.
Ohsawa F, Yamada S, Yakushiji N, Shinozaki R, Nakayama M, Kawata K, Hagaya M, Kobayashi T, Kohara K, Furusawa Y, Fujiwara C, Ohta Y, Makishima M, Naitou H, Tai A, Yoshikawa Y, Yasui H, Kakuta H. Ohsawa F, et al. Among authors: kakuta h. J Med Chem. 2013 Mar 14;56(5):1865-77. doi: 10.1021/jm400033f. Epub 2013 Feb 20. J Med Chem. 2013. PMID: 23391145
Retinoid X receptor ligands: a patent review (2007 - 2013).
Yamada S, Kakuta H. Yamada S, et al. Among authors: kakuta h. Expert Opin Ther Pat. 2014 Apr;24(4):443-52. doi: 10.1517/13543776.2014.880692. Epub 2014 Jan 24. Expert Opin Ther Pat. 2014. PMID: 24456080 Review.
RXR partial agonist produced by side chain repositioning of alkoxy RXR full agonist retains antitype 2 diabetes activity without the adverse effects.
Kawata K, Morishita K, Nakayama M, Yamada S, Kobayashi T, Furusawa Y, Arimoto-Kobayashi S, Oohashi T, Makishima M, Naitou H, Ishitsubo E, Tokiwa H, Tai A, Kakuta H. Kawata K, et al. Among authors: kakuta h. J Med Chem. 2015 Jan 22;58(2):912-26. doi: 10.1021/jm501863r. Epub 2014 Dec 17. J Med Chem. 2015. PMID: 25486327
Synthesis of 11C-Labeled RXR Partial Agonist 1-[(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic Acid (CBt-PMN) by Direct [11C]Carbon Dioxide Fixation via Organolithiation of Trialkyltin Precursor and PET Imaging Thereof.
Shibahara O, Watanabe M, Yamada S, Akehi M, Sasaki T, Akahoshi A, Hanada T, Hirano H, Nakatani S, Nishioka H, Takeuchi Y, Kakuta H. Shibahara O, et al. Among authors: kakuta h. J Med Chem. 2017 Aug 24;60(16):7139-7145. doi: 10.1021/acs.jmedchem.7b00817. Epub 2017 Aug 14. J Med Chem. 2017. PMID: 28753292
181 results