Kakularam KR - Search Results

1

Oxygenation of endocannabinoids by mammalian lipoxygenase isoforms.

Ivanov I, Kakularam KR, Shmendel EV, Rothe M, Aparoy P, Heydeck D, Kuhn H. Ivanov I, et al. Among authors: kakularam kr. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Jun;1866(6):158918. doi: 10.1016/j.bbalip.2021.158918. Epub 2021 Mar 2. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 33662546

2

Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants.

Hofheinz K, Kakularam KR, Adel S, Anton M, Polymarasetty A, Reddanna P, Kuhn H, Horn T. Hofheinz K, et al. Among authors: kakularam kr. Arch Biochem Biophys. 2013 Feb 1;530(1):40-7. doi: 10.1016/j.abb.2012.11.015. Epub 2012 Dec 12. Arch Biochem Biophys. 2013. PMID: 23246375

3

Molecular basis for the catalytic inactivity of a naturally occurring near-null variant of human ALOX15.

Horn T, Ivanov I, Di Venere A, Kakularam KR, Reddanna P, Conrad ML, Richter C, Scheerer P, Kuhn H. Horn T, et al. Among authors: kakularam kr. Biochim Biophys Acta. 2013 Dec;1831(12):1702-13. doi: 10.1016/j.bbalip.2013.08.004. Epub 2013 Aug 16. Biochim Biophys Acta. 2013. PMID: 23958500

4

Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling.

Horn T, Adel S, Schumann R, Sur S, Kakularam KR, Polamarasetty A, Redanna P, Kuhn H, Heydeck D. Horn T, et al. Among authors: kakularam kr. Prog Lipid Res. 2015 Jan;57:13-39. doi: 10.1016/j.plipres.2014.11.001. Epub 2014 Nov 28. Prog Lipid Res. 2015. PMID: 25435097 Free PMC article. Review.

5

Leukotriene signaling in the extinct human subspecies Homo denisovan and Homo neanderthalensis. Structural and functional comparison with Homo sapiens.

Adel S, Kakularam KR, Horn T, Reddanna P, Kuhn H, Heydeck D. Adel S, et al. Among authors: kakularam kr. Arch Biochem Biophys. 2015 Jan 1;565:17-24. doi: 10.1016/j.abb.2014.10.012. Epub 2014 Nov 1. Arch Biochem Biophys. 2015. PMID: 25447821

6

Understanding the Dual Inhibition of COX-2 and Carbonic Anhydrase-II by Celecoxib and CG100649 Using Density Functional Theory Calculations and other Molecular Modelling Approaches.

Singh O, Kakularam KR, Reddanna P, Aparoy P. Singh O, et al. Among authors: kakularam kr. Protein Pept Lett. 2015;22(10):903-12. doi: 10.2174/0929866522666150622102131. Protein Pept Lett. 2015. PMID: 26095375

7

Thr92Ala polymorphism in the type 2 deiodinase gene: an evolutionary perspective.

Ricci C, Kakularam KR, Marzocchi C, Capecchi G, Riolo G, Boschin F, Kuhn H, Castagna MG, Cantara S. Ricci C, et al. Among authors: kakularam kr. J Endocrinol Invest. 2020 Dec;43(12):1749-1757. doi: 10.1007/s40618-020-01287-5. Epub 2020 May 20. J Endocrinol Invest. 2020. PMID: 32436183

8

Eicosanoid biosynthesis in marine mammals.

Reisch F, Kakularam KR, Stehling S, Heydeck D, Kuhn H. Reisch F, et al. Among authors: kakularam kr. FEBS J. 2021 Feb;288(4):1387-1406. doi: 10.1111/febs.15469. Epub 2020 Jul 18. FEBS J. 2021. PMID: 32627384 Free article.

9

Paralog- and ortholog-specificity of inhibitors of human and mouse lipoxygenase-isoforms.

Kakularam KR, Karst F, Polamarasetty A, Ivanov I, Heydeck D, Kuhn H. Kakularam KR, et al. Biomed Pharmacother. 2022 Jan;145:112434. doi: 10.1016/j.biopha.2021.112434. Epub 2021 Nov 19. Biomed Pharmacother. 2022. PMID: 34801853 Free article.

10

N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action.

Golovanov A, Zhuravlev A, Cruz A, Aksenov V, Shafiullina R, Kakularam KR, Lluch JM, Kuhn H, González-Lafont À, Ivanov I. Golovanov A, et al. Among authors: kakularam kr. J Med Chem. 2022 Feb 10;65(3):1979-1995. doi: 10.1021/acs.jmedchem.1c01563. Epub 2022 Jan 25. J Med Chem. 2022. PMID: 35073698

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