Kakuda N - Search Results

1

Suspected limited efficacy of γ-secretase modulators.

Kakuda N, Akazawa K, Hatsuta H, Murayama S, Ihara Y; Japanese Alzheimer's Disease Neuroimaging Initiative. Kakuda N, et al. Neurobiol Aging. 2013 Apr;34(4):1101-4. doi: 10.1016/j.neurobiolaging.2012.08.017. Epub 2012 Oct 9. Neurobiol Aging. 2013. PMID: 23058852

2

Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein.

Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y. Sato T, et al. Among authors: kakuda n. J Biol Chem. 2003 Jul 4;278(27):24294-301. doi: 10.1074/jbc.M211161200. Epub 2003 Apr 21. J Biol Chem. 2003. PMID: 12707272 Free article.

3

Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.

Kakuda N, Funamoto S, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y. Kakuda N, et al. J Biol Chem. 2006 May 26;281(21):14776-86. doi: 10.1074/jbc.M513453200. Epub 2006 Apr 4. J Biol Chem. 2006. PMID: 16595682 Free article.

4

Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice.

Mori T, Rezai-Zadeh K, Koyama N, Arendash GW, Yamaguchi H, Kakuda N, Horikoshi-Sakuraba Y, Tan J, Town T. Mori T, et al. Among authors: kakuda n. J Biol Chem. 2012 Feb 24;287(9):6912-27. doi: 10.1074/jbc.M111.294025. Epub 2012 Jan 4. J Biol Chem. 2012. PMID: 22219198 Free PMC article.

5

Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease.

Kakuda N, Shoji M, Arai H, Furukawa K, Ikeuchi T, Akazawa K, Takami M, Hatsuta H, Murayama S, Hashimoto Y, Miyajima M, Arai H, Nagashima Y, Yamaguchi H, Kuwano R, Nagaike K, Ihara Y; Japanese Alzheimer's Disease Neuroimaging Initiative. Kakuda N, et al. EMBO Mol Med. 2012 Apr;4(4):344-52. doi: 10.1002/emmm.201200214. Epub 2012 Feb 21. EMBO Mol Med. 2012. PMID: 22354516 Free PMC article.

6

[Amyloid beta protein of CSF].

Kakuda N, Ihara Y. Kakuda N, et al. Nihon Rinsho. 2011 Oct;69 Suppl 8:542-5. Nihon Rinsho. 2011. PMID: 22787847 Japanese. No abstract available.

7

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.

Funamoto S, Sasaki T, Ishihara S, Nobuhara M, Nakano M, Watanabe-Takahashi M, Saito T, Kakuda N, Miyasaka T, Nishikawa K, Saido TC, Ihara Y. Funamoto S, et al. Among authors: kakuda n. Nat Commun. 2013;4:2529. doi: 10.1038/ncomms3529. Nat Commun. 2013. PMID: 24108142 Free PMC article.

8

Distinct deposition of amyloid-β species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry.

Kakuda N, Miyasaka T, Iwasaki N, Nirasawa T, Wada-Kakuda S, Takahashi-Fujigasaki J, Murayama S, Ihara Y, Ikegawa M. Kakuda N, et al. Acta Neuropathol Commun. 2017 Oct 16;5(1):73. doi: 10.1186/s40478-017-0477-x. Acta Neuropathol Commun. 2017. PMID: 29037261 Free PMC article.

9

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry.

Ikegawa M, Nirasawa T, Kakuda N, Miyasaka T, Kuzuhara Y, Murayama S, Ihara Y. Ikegawa M, et al. Among authors: kakuda n. J Vis Exp. 2019 Mar 7;(145). doi: 10.3791/57645. J Vis Exp. 2019. PMID: 30907869

10

γ-Secretase Activity Is Associated with Braak Senile Plaque Stages.

Kakuda N, Yamaguchi H, Akazawa K, Hata S, Suzuki T, Hatsuta H, Murayama S, Funamoto S, Ihara Y. Kakuda N, et al. Am J Pathol. 2020 Jun;190(6):1323-1331. doi: 10.1016/j.ajpath.2020.02.009. Epub 2020 Mar 20. Am J Pathol. 2020. PMID: 32201261 Free article.

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