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KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels.
Tsuji S, Otani C, Horie T, Watanabe S, Baba O, Sowa N, Ide Y, Kashiwa A, Makiyama T, Imai H, Nakashima Y, Yamasaki T, Xu S, Matsushita K, Suzuki K, Zou F, Kume E, Hasegawa K, Kimura T, Kakizuka A, Ono K. Tsuji S, et al. Among authors: kakizuka a. Biomed Pharmacother. 2024 Jan;170:115850. doi: 10.1016/j.biopha.2023.115850. Epub 2023 Dec 12. Biomed Pharmacother. 2024. PMID: 38091636 Free article.
A novel VCP modulator KUS121 exerts renoprotective effects in ischemia-reperfusion injury with retaining ATP and restoring ERAD-processing capacity.
Hata Y, Date R, Fujimoto D, Ikeda HO, Umemoto S, Kanki T, Nishiguchi Y, Mizumoto T, Hayata M, Kakizoe Y, Izumi Y, Kakizuka A, Mukoyama M, Kuwabara T. Hata Y, et al. Among authors: kakizuka a. Am J Physiol Renal Physiol. 2022 May 1;322(5):F577-F586. doi: 10.1152/ajprenal.00392.2021. Epub 2022 Mar 28. Am J Physiol Renal Physiol. 2022. PMID: 35343850 Free article.
Author Correction: A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis.
Saito M, Nishitani K, Ikeda HO, Yoshida S, Iwai S, Ji X, Nakahata A, Ito A, Nakamura S, Kuriyama S, Yoshitomi H, Murata K, Aoyama T, Ito H, Kuroki H, Kakizuka A, Matsuda S. Saito M, et al. Among authors: kakizuka a. Sci Rep. 2021 Mar 29;11(1):7442. doi: 10.1038/s41598-021-86883-y. Sci Rep. 2021. PMID: 33782495 Free PMC article. No abstract available.
159 results