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Molecular clearance of ataxin-3 is regulated by a mammalian E4.
Matsumoto M, Yada M, Hatakeyama S, Ishimoto H, Tanimura T, Tsuji S, Kakizuka A, Kitagawa M, Nakayama KI. Matsumoto M, et al. Among authors: kakizuka a. EMBO J. 2004 Feb 11;23(3):659-69. doi: 10.1038/sj.emboj.7600081. Epub 2004 Jan 29. EMBO J. 2004. PMID: 14749733 Free PMC article.
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR. Wellington CL, et al. Among authors: kakizuka a. J Biol Chem. 1998 Apr 10;273(15):9158-67. doi: 10.1074/jbc.273.15.9158. J Biol Chem. 1998. PMID: 9535906 Free article.
A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
Goti D, Katzen SM, Mez J, Kurtis N, Kiluk J, Ben-Haïem L, Jenkins NA, Copeland NG, Kakizuka A, Sharp AH, Ross CA, Mouton PR, Colomer V. Goti D, et al. Among authors: kakizuka a. J Neurosci. 2004 Nov 10;24(45):10266-79. doi: 10.1523/JNEUROSCI.2734-04.2004. J Neurosci. 2004. PMID: 15537899 Free PMC article.
[Therapeutic targets in polyglutamine diseases].
Hori S, Kakizuka A. Hori S, et al. Among authors: kakizuka a. Tanpakushitsu Kakusan Koso. 2004 May;49(7 Suppl):1118-21. Tanpakushitsu Kakusan Koso. 2004. PMID: 15168543 Review. Japanese. No abstract available.
159 results