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RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane.
Yokoyama S, Kawai T, Yamamoto K, Yibin H, Yamamoto H, Kakino A, Takeshita H, Nozato Y, Fujimoto T, Hongyo K, Takahashi T, Nakagami F, Akasaka H, Takami Y, Takeya Y, Sugimoto K, Sawamura T, Rakugi H. Yokoyama S, et al. Among authors: kakino a. Sci Rep. 2021 Mar 11;11(1):5759. doi: 10.1038/s41598-021-85312-4. Sci Rep. 2021. PMID: 33707701 Free PMC article.
LOX-1 mediates vascular lipid retention under hypertensive state.
Nakano A, Inoue N, Sato Y, Nishimichi N, Takikawa K, Fujita Y, Kakino A, Otsui K, Yamaguchi S, Matsuda H, Sawamura T. Nakano A, et al. Among authors: kakino a. J Hypertens. 2010 Jun;28(6):1273-80. doi: 10.1097/HJH.0b013e32833835d4. J Hypertens. 2010. PMID: 20216085
Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox.
Nishizuka T, Fujita Y, Sato Y, Nakano A, Kakino A, Ohshima S, Kanda T, Yoshimoto R, Sawamura T. Nishizuka T, et al. Among authors: kakino a. Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(3):104-13. doi: 10.2183/pjab.87.104. Proc Jpn Acad Ser B Phys Biol Sci. 2011. PMID: 21422743 Free PMC article.
The discovery of LOX-1, its ligands and clinical significance.
Yoshimoto R, Fujita Y, Kakino A, Iwamoto S, Takaya T, Sawamura T. Yoshimoto R, et al. Among authors: kakino a. Cardiovasc Drugs Ther. 2011 Oct;25(5):379-91. doi: 10.1007/s10557-011-6324-6. Cardiovasc Drugs Ther. 2011. PMID: 21805404 Free PMC article. Review.
Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.
Ishikawa M, Ito H, Akiyoshi M, Kume N, Yoshitomi H, Mitsuoka H, Tanida S, Murata K, Shibuya H, Kasahara T, Kakino A, Fujita Y, Sawamura T, Yasuda T, Nakamura T. Ishikawa M, et al. Among authors: kakino a. Arthritis Rheum. 2012 Apr;64(4):1024-34. doi: 10.1002/art.33452. Epub 2011 Nov 10. Arthritis Rheum. 2012. PMID: 22076918 Free article.
46 results