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Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma.
Schäfer D, Tomiuk S, Küster LN, Rawashdeh WA, Henze J, Tischler-Höhle G, Agorku DJ, Brauner J, Linnartz C, Lock D, Kaiser A, Herbel C, Eckardt D, Lamorte M, Lenhard D, Schüler J, Ströbel P, Missbach-Guentner J, Pinkert-Leetsch D, Alves F, Bosio A, Hardt O. Schäfer D, et al. Among authors: kaiser a. Nat Commun. 2021 Mar 5;12(1):1453. doi: 10.1038/s41467-021-21774-4. Nat Commun. 2021. PMID: 33674603 Free PMC article.
CD137+CD154- Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures.
Nowak A, Lock D, Bacher P, Hohnstein T, Vogt K, Gottfreund J, Giehr P, Polansky JK, Sawitzki B, Kaiser A, Walter J, Scheffold A. Nowak A, et al. Among authors: kaiser a. Front Immunol. 2018 Feb 7;9:199. doi: 10.3389/fimmu.2018.00199. eCollection 2018. Front Immunol. 2018. PMID: 29467769 Free PMC article.
Automated generation of gene-edited CAR T cells at clinical scale.
Alzubi J, Lock D, Rhiel M, Schmitz S, Wild S, Mussolino C, Hildenbeutel M, Brandes C, Rositzka J, Lennartz S, Haas SA, Chmielewski KO, Schaser T, Kaiser A, Cathomen T, Cornu TI. Alzubi J, et al. Among authors: kaiser a. Mol Ther Methods Clin Dev. 2020 Dec 25;20:379-388. doi: 10.1016/j.omtm.2020.12.008. eCollection 2021 Mar 12. Mol Ther Methods Clin Dev. 2020. PMID: 33575430 Free PMC article.
Anti-CD19 CARs displayed at the surface of lentiviral vector particles promote transduction of target-expressing cells.
Cordes N, Kolbe C, Lock D, Holzer T, Althoff D, Schäfer D, Blaeschke F, Kotter B, Karitzky S, Rossig C, Cathomen T, Feuchtinger T, Bürger I, Assenmacher M, Schaser T, Kaiser AD. Cordes N, et al. Mol Ther Methods Clin Dev. 2021 Feb 24;21:42-53. doi: 10.1016/j.omtm.2021.02.013. eCollection 2021 Jun 11. Mol Ther Methods Clin Dev. 2021. PMID: 33768128 Free PMC article.
Novel adapter CAR-T cell technology for precisely controllable multiplex cancer targeting.
Seitz CM, Mittelstaet J, Atar D, Hau J, Reiter S, Illi C, Kieble V, Engert F, Drees B, Bender G, Krahl AC, Knopf P, Schroeder S, Paulsen N, Rokhvarguer A, Scheuermann S, Rapp E, Mast AS, Rabsteyn A, Schleicher S, Grote S, Schilbach K, Kneilling M, Pichler B, Lock D, Kotter B, Dapa S, Miltenyi S, Kaiser A, Lang P, Handgretinger R, Schlegel P. Seitz CM, et al. Among authors: kaiser a. Oncoimmunology. 2021 Dec 2;10(1):2003532. doi: 10.1080/2162402X.2021.2003532. eCollection 2021. Oncoimmunology. 2021. PMID: 35686214 Free PMC article.
Automated, scaled, transposon-based production of CAR T cells.
Lock D, Monjezi R, Brandes C, Bates S, Lennartz S, Teppert K, Gehrke L, Karasakalidou-Seidt R, Lukic T, Schmeer M, Schleef M, Werchau N, Eyrich M, Assenmacher M, Kaiser A, Prommersberger S, Schaser T, Hudecek M. Lock D, et al. Among authors: kaiser a. J Immunother Cancer. 2022 Sep;10(9):e005189. doi: 10.1136/jitc-2022-005189. J Immunother Cancer. 2022. PMID: 36096530 Free PMC article.
Combined targeting of soluble latent TGF-ß and a solid tumor-associated antigen with adapter CAR T cells.
Werchau N, Kotter B, Criado-Moronati E, Gosselink A, Cordes N, Lock D, Lennartz S, Kolbe C, Winter N, Teppert K, Engert F, Webster B, Mittelstaet J, Schaefer D, Mallmann P, Mallmann MR, Ratiu D, Assenmacher M, Schaser T, von Bergwelt-Baildon M, Abramowski P, Kaiser AD. Werchau N, et al. Among authors: kaiser ad. Oncoimmunology. 2022 Nov 11;11(1):2140534. doi: 10.1080/2162402X.2022.2140534. eCollection 2022. Oncoimmunology. 2022. PMID: 36387056 Free PMC article.
1,215 results