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Anti-Virulence Therapeutic Approaches for Neisseria gonorrhoeae.
Lim KYL, Mullally CA, Haese EC, Kibble EA, McCluskey NR, Mikucki EC, Thai VC, Stubbs KA, Sarkar-Tyson M, Kahler CM. Lim KYL, et al. Among authors: kahler cm. Antibiotics (Basel). 2021 Jan 21;10(2):103. doi: 10.3390/antibiotics10020103. Antibiotics (Basel). 2021. PMID: 33494538 Free PMC article. Review.
Enzyme targets for drug design of new anti-virulence therapeutics.
Kahler CM, Sarkar-Tyson M, Kibble EA, Stubbs KA, Vrielink A. Kahler CM, et al. Curr Opin Struct Biol. 2018 Dec;53:140-150. doi: 10.1016/j.sbi.2018.08.010. Epub 2018 Sep 14. Curr Opin Struct Biol. 2018. PMID: 30223251 Free article. Review.
Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase.
Mullally C, Stubbs KA, Thai VC, Anandan A, Bartley S, Scanlon MJ, Jarvis GA, John CM, Lim KYL, Sullivan CM, Sarkar-Tyson M, Vrielink A, Kahler CM. Mullally C, et al. Among authors: kahler cm. J Antimicrob Chemother. 2022 Aug 25;77(9):2441-2447. doi: 10.1093/jac/dkac204. J Antimicrob Chemother. 2022. PMID: 35770844 Free PMC article.
Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major.
Iwasaki J, Lorimer DD, Vivoli-Vega M, Kibble EA, Peacock CS, Abendroth J, Mayclin SJ, Dranow DM, Pierce PG, Fox D, Lewis M, Bzdyl NM, Kristensen SS, Inglis TJJ, Kahler CM, Bond CS, Hasenkopf A, Seufert F, Schmitz J, Marshall LE, Scott AE, Norville IH, Myler PJ, Holzgrabe U, Harmer NJ, Sarkar-Tyson M. Iwasaki J, et al. Among authors: kahler cm. J Antimicrob Chemother. 2022 May 29;77(6):1625-1634. doi: 10.1093/jac/dkac065. J Antimicrob Chemother. 2022. PMID: 35245364 Free PMC article.
156 results