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Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability.
Aragonès G, Dasuri K, Olukorede O, Francisco SG, Renneburg C, Kumsta C, Hansen M, Kageyama S, Komatsu M, Rowan S, Volkin J, Workman M, Yang W, Daza P, Ruano D, Dominguez-Martín H, Rodríguez-Navarro JA, Du XL, Brownlee MA, Bejarano E, Taylor A. Aragonès G, et al. Among authors: kageyama s. Aging Cell. 2020 Nov;19(11):e13257. doi: 10.1111/acel.13257. Epub 2020 Nov 4. Aging Cell. 2020. PMID: 33146912 Free PMC article.
p62/SQSTM1/A170: physiology and pathology.
Komatsu M, Kageyama S, Ichimura Y. Komatsu M, et al. Among authors: kageyama s. Pharmacol Res. 2012 Dec;66(6):457-62. doi: 10.1016/j.phrs.2012.07.004. Epub 2012 Jul 25. Pharmacol Res. 2012. PMID: 22841931 Review.
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M. Ichimura Y, et al. Among authors: kageyama s. Mol Cell. 2013 Sep 12;51(5):618-31. doi: 10.1016/j.molcel.2013.08.003. Epub 2013 Sep 5. Mol Cell. 2013. PMID: 24011591 Free article.
LC3B is indispensable for selective autophagy of p62 but not basal autophagy.
Maruyama Y, Sou YS, Kageyama S, Takahashi T, Ueno T, Tanaka K, Komatsu M, Ichimura Y. Maruyama Y, et al. Among authors: kageyama s. Biochem Biophys Res Commun. 2014 Mar 28;446(1):309-15. doi: 10.1016/j.bbrc.2014.02.093. Epub 2014 Feb 28. Biochem Biophys Res Commun. 2014. PMID: 24582747
NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system.
Sánchez-Martín P, Sou YS, Kageyama S, Koike M, Waguri S, Komatsu M. Sánchez-Martín P, et al. Among authors: kageyama s. EMBO Rep. 2020 Mar 4;21(3):e48902. doi: 10.15252/embr.201948902. Epub 2020 Jan 9. EMBO Rep. 2020. PMID: 31916398 Free PMC article.
p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response.
Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M. Kageyama S, et al. Nat Commun. 2021 Jan 4;12(1):16. doi: 10.1038/s41467-020-20185-1. Nat Commun. 2021. PMID: 33397898 Free PMC article.
829 results