Kaech SM - Search Results

1

Mitochondrial DNA stress primes the antiviral innate immune response.

West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS. West AP, et al. Among authors: kaech sm. Nature. 2015 Apr 23;520(7548):553-7. doi: 10.1038/nature14156. Epub 2015 Feb 2. Nature. 2015. PMID: 25642965 Free PMC article.

2

Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation.

D'Souza AD, Parikh N, Kaech SM, Shadel GS. D'Souza AD, et al. Among authors: kaech sm. Mitochondrion. 2007 Dec;7(6):374-85. doi: 10.1016/j.mito.2007.08.001. Epub 2007 Aug 16. Mitochondrion. 2007. PMID: 17890163 Free PMC article.

3

Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling.

D'Souza AD, Parish IA, McKay SE, Kaech SM, Shadel GS. D'Souza AD, et al. Among authors: kaech sm. Am J Pathol. 2011 Jun;178(6):2740-51. doi: 10.1016/j.ajpath.2011.02.022. Am J Pathol. 2011. PMID: 21641396 Free PMC article.

4

Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia.

D'Souza AD, Parish IA, Krause DS, Kaech SM, Shadel GS. D'Souza AD, et al. Among authors: kaech sm. Mol Ther. 2013 Jan;21(1):42-8. doi: 10.1038/mt.2012.203. Epub 2012 Sep 25. Mol Ther. 2013. PMID: 23011031 Free PMC article.

5

The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis.

Henao-Mejia J, Williams A, Goff LA, Staron M, Licona-Limón P, Kaech SM, Nakayama M, Rinn JL, Flavell RA. Henao-Mejia J, et al. Among authors: kaech sm. Immunity. 2013 May 23;38(5):984-97. doi: 10.1016/j.immuni.2013.02.021. Epub 2013 Apr 25. Immunity. 2013. PMID: 23623381 Free PMC article.

6

Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells.

Ray JP, Marshall HD, Laidlaw BJ, Staron MM, Kaech SM, Craft J. Ray JP, et al. Among authors: kaech sm. Immunity. 2014 Mar 20;40(3):367-77. doi: 10.1016/j.immuni.2014.02.005. Epub 2014 Mar 13. Immunity. 2014. PMID: 24631156 Free PMC article.

7

The interface between transcriptional and epigenetic control of effector and memory CD8⁺ T-cell differentiation.

Gray SM, Kaech SM, Staron MM. Gray SM, et al. Among authors: kaech sm. Immunol Rev. 2014 Sep;261(1):157-68. doi: 10.1111/imr.12205. Immunol Rev. 2014. PMID: 25123283 Free PMC article. Review.

8

A central role for Notch in effector CD8(+) T cell differentiation.

Backer RA, Helbig C, Gentek R, Kent A, Laidlaw BJ, Dominguez CX, de Souza YS, van Trierum SE, van Beek R, Rimmelzwaan GF, ten Brinke A, Willemsen AM, van Kampen AH, Kaech SM, Blander JM, van Gisbergen K, Amsen D. Backer RA, et al. Among authors: kaech sm. Nat Immunol. 2014 Dec;15(12):1143-51. doi: 10.1038/ni.3027. Epub 2014 Oct 26. Nat Immunol. 2014. PMID: 25344724 Free PMC article.

9

The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection.

Staron MM, Gray SM, Marshall HD, Parish IA, Chen JH, Perry CJ, Cui G, Li MO, Kaech SM. Staron MM, et al. Among authors: kaech sm. Immunity. 2014 Nov 20;41(5):802-14. doi: 10.1016/j.immuni.2014.10.013. Epub 2014 Nov 13. Immunity. 2014. PMID: 25464856 Free PMC article.

10

The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa.

Marshall HD, Ray JP, Laidlaw BJ, Zhang N, Gawande D, Staron MM, Craft J, Kaech SM. Marshall HD, et al. Among authors: kaech sm. Elife. 2015 Jan 8;4:e04851. doi: 10.7554/eLife.04851. Elife. 2015. PMID: 25569154 Free PMC article.

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