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The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.
Hashimoto Y, Niikura T, Chiba T, Tsukamoto E, Kadowaki H, Nishitoh H, Yamagishi Y, Ishizaka M, Yamada M, Nawa M, Terashita K, Aiso S, Ichijo H, Nishimoto I. Hashimoto Y, et al. Among authors: kadowaki h. J Pharmacol Exp Ther. 2003 Sep;306(3):889-902. doi: 10.1124/jpet.103.051383. Epub 2003 Jun 26. J Pharmacol Exp Ther. 2003. PMID: 12829723
USP14 inhibits ER-associated degradation via interaction with IRE1alpha.
Nagai A, Kadowaki H, Maruyama T, Takeda K, Nishitoh H, Ichijo H. Nagai A, et al. Among authors: kadowaki h. Biochem Biophys Res Commun. 2009 Feb 20;379(4):995-1000. doi: 10.1016/j.bbrc.2008.12.182. Epub 2009 Jan 9. Biochem Biophys Res Commun. 2009. PMID: 19135427
242 results