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Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists.
Yrjölä S, Parkkari T, Navia-Paldanius D, Laitinen T, Kaczor AA, Kokkola T, Adusei-Mensah F, Savinainen JR, Laitinen JT, Poso A, Alexander A, Penman J, Stott L, Anskat M, Irving AJ, Nevalainen TJ. Yrjölä S, et al. Among authors: kaczor aa. Eur J Med Chem. 2016 Jan 1;107:119-32. doi: 10.1016/j.ejmech.2015.10.050. Epub 2015 Nov 2. Eur J Med Chem. 2016. PMID: 26575458
Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.
Patel JZ, Parkkari T, Laitinen T, Kaczor AA, Saario SM, Savinainen JR, Navia-Paldanius D, Cipriano M, Leppänen J, Koshevoy IO, Poso A, Fowler CJ, Laitinen JT, Nevalainen T. Patel JZ, et al. Among authors: kaczor aa. J Med Chem. 2013 Nov 14;56(21):8484-96. doi: 10.1021/jm400923s. Epub 2013 Oct 22. J Med Chem. 2013. PMID: 24083878
Application of BRET for studying G protein-coupled receptors.
Kaczor AA, Makarska-Bialokoz M, Selent J, de la Fuente RA, Martí-Solano M, Castro M. Kaczor AA, et al. Mini Rev Med Chem. 2014 May;14(5):411-25. doi: 10.2174/1389557514666140428113708. Mini Rev Med Chem. 2014. PMID: 24766382 Review.
Synthesis, in vitro and in vivo studies, and molecular modeling of N-alkylated dextromethorphan derivatives as non-competitive inhibitors of α3β4 nicotinic acetylcholine receptor.
Jozwiak K, Targowska-Duda KM, Kaczor AA, Kozak J, Ligeza A, Szacon E, Wrobel TM, Budzynska B, Biala G, Fornal E, Poso A, Wainer IW, Matosiuk D. Jozwiak K, et al. Among authors: kaczor aa. Bioorg Med Chem. 2014 Dec 15;22(24):6846-56. doi: 10.1016/j.bmc.2014.10.036. Epub 2014 Oct 31. Bioorg Med Chem. 2014. PMID: 25464883
Pharmacological and molecular studies on the interaction of varenicline with different nicotinic acetylcholine receptor subtypes. Potential mechanism underlying partial agonism at human α4β2 and α3β4 subtypes.
Arias HR, Feuerbach D, Targowska-Duda K, Kaczor AA, Poso A, Jozwiak K. Arias HR, et al. Among authors: kaczor aa. Biochim Biophys Acta. 2015 Feb;1848(2):731-41. doi: 10.1016/j.bbamem.2014.11.003. Epub 2014 Dec 2. Biochim Biophys Acta. 2015. PMID: 25475645 Free article.
103 results