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A landmark in drug discovery based on complex natural product synthesis.
Kawano S, Ito K, Yahata K, Kira K, Abe T, Akagi T, Asano M, Iso K, Sato Y, Matsuura F, Ohashi I, Matsumoto Y, Isomura M, Sasaki T, Fukuyama T, Miyashita Y, Kaburagi Y, Yokoi A, Asano O, Owa T, Kishi Y. Kawano S, et al. Among authors: kaburagi y. Sci Rep. 2019 Jun 17;9(1):8656. doi: 10.1038/s41598-019-45001-9. Sci Rep. 2019. PMID: 31209263 Free PMC article.
Ten-Gram-Scale Total Synthesis of the Anticancer Drug Candidate E7130 to Supply Clinical Trials.
Kaburagi Y, Kira K, Yahata K, Iso K, Sato Y, Matsuura F, Ohashi I, Matsumoto Y, Isomura M, Sasaki T, Fukuyama T, Miyashita Y, Azuma H, Iida D, Ishida T, Itano W, Matsuda M, Matsukura M, Murai N, Nagao S, Seki M, Yamamoto A, Yamamoto Y, Yoneda N, Watanabe Y, Kamada A, Kayano A, Tagami K, Asano O, Owa T, Kishi Y. Kaburagi Y, et al. Org Lett. 2024 Apr 12;26(14):2837-2842. doi: 10.1021/acs.orglett.3c03663. Epub 2024 Jan 22. Org Lett. 2024. PMID: 38252895
Total synthesis of (-)-strychnine.
Kaburagi Y, Tokuyama H, Fukuyama T. Kaburagi Y, et al. J Am Chem Soc. 2004 Aug 25;126(33):10246-7. doi: 10.1021/ja046407b. J Am Chem Soc. 2004. PMID: 15315428
Total synthesis of leustroducsin B.
Shimada K, Kaburagi Y, Fukuyama T. Shimada K, et al. Among authors: kaburagi y. J Am Chem Soc. 2003 Apr 9;125(14):4048-9. doi: 10.1021/ja0340679. J Am Chem Soc. 2003. PMID: 12670216
Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models.
Matsukawa T, Yagi T, Uchida T, Sakai M, Mitsushima M, Naganuma T, Yano H, Inaba Y, Inoue H, Yanagida K, Uematsu M, Nakao K, Nakao H, Aiba A, Nagashima Y, Kubota T, Kubota N, Izumida Y, Yahagi N, Unoki-Kubota H, Kaburagi Y, Asahara SI, Kido Y, Shindou H, Itoh M, Ogawa Y, Minami S, Terauchi Y, Tobe K, Ueki K, Kasuga M, Matsumoto M. Matsukawa T, et al. Among authors: kaburagi y. JCI Insight. 2023 Sep 8;8(17):e161282. doi: 10.1172/jci.insight.161282. JCI Insight. 2023. PMID: 37681411 Free PMC article.
Independent risk factors of rapid glomerular filtration rate decline in patients with type 2 diabetes with preserved kidney function and normoalbuminuria: A multicenter cohort study.
Hirano D, Unoki-Kubota H, Imasawa T, Yamamoto-Honda R, Kajio H, Yamashita S, Fukazawa Y, Seki N, Noda M, Kaburagi Y. Hirano D, et al. Among authors: kaburagi y. J Diabetes Investig. 2023 Jul;14(7):874-882. doi: 10.1111/jdi.14011. Epub 2023 Apr 6. J Diabetes Investig. 2023. PMID: 37026171 Free PMC article.
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