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Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited.
Nat Metab. 2022 Jun;4(6):711-723. doi: 10.1038/s42255-022-00588-8. Epub 2022 Jun 23.
Nat Metab. 2022.
PMID: 35739397
Free PMC article.
Increased demand for NAD+ relative to ATP drives aerobic glycolysis.
Luengo A, Li Z, Gui DY, Sullivan LB, Zagorulya M, Do BT, Ferreira R, Naamati A, Ali A, Lewis CA, Thomas CJ, Spranger S, Matheson NJ, Vander Heiden MG.
Luengo A, et al.
Mol Cell. 2021 Feb 18;81(4):691-707.e6. doi: 10.1016/j.molcel.2020.12.012. Epub 2020 Dec 30.
Mol Cell. 2021.
PMID: 33382985
Free PMC article.
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Aspartate is an endogenous metabolic limitation for tumour growth.
Sullivan LB, Luengo A, Danai LV, Bush LN, Diehl FF, Hosios AM, Lau AN, Elmiligy S, Malstrom S, Lewis CA, Vander Heiden MG.
Sullivan LB, et al.
Nat Cell Biol. 2018 Jul;20(7):782-788. doi: 10.1038/s41556-018-0125-0. Epub 2018 Jun 25.
Nat Cell Biol. 2018.
PMID: 29941931
Free PMC article.
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