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32 results

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First-in-Human Clinical Trial to Assess the Safety, Tolerability and Pharmacokinetics of Single Doses of NTM-1633, a Novel Mixture of Monoclonal Antibodies against Botulinum Toxin E.
Raja SM, Guptill JT, Juel VC, Walter EB, Cohen-Wolkowiez M, Hill H, Sendra E, Hauser B, Jackson P, Tomic M, Espinoza Y, Swamy GK. Raja SM, et al. Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0173221. doi: 10.1128/aac.01732-21. Epub 2022 Mar 21. Antimicrob Agents Chemother. 2022. PMID: 35311524 Free PMC article. Clinical Trial.
Reduced plasmablast frequency is associated with seronegative myasthenia gravis.
Guptill JT, Barfield R, Chan C, Russo MA, Emmett D, Raja S, Massey JM, Juel VC, Hobson-Webb LD, Gable KL, Gonzalez N, Hammett A, Howard JF Jr, Chopra M, Kaminski HJ, Siddiqi ZA, Migdal M, Yi JS. Guptill JT, et al. Muscle Nerve. 2021 Apr;63(4):577-585. doi: 10.1002/mus.27140. Epub 2020 Dec 24. Muscle Nerve. 2021. PMID: 33294984 Free PMC article.
First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers.
Van Eldik LJ, Sawaki L, Bowen K, Laskowitz DT, Noveck RJ, Hauser B, Jordan L, Spears TG, Wu H, Watt K, Raja S, Roy SM, Watterson DM, Guptill JT. Van Eldik LJ, et al. Clin Pharmacol Drug Dev. 2021 Feb;10(2):131-143. doi: 10.1002/cpdd.795. Epub 2020 Apr 7. Clin Pharmacol Drug Dev. 2021. PMID: 32255549 Free PMC article. Clinical Trial.
Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial.
Bernstein DI, Guptill J, Naficy A, Nachbagauer R, Berlanda-Scorza F, Feser J, Wilson PC, Solórzano A, Van der Wielen M, Walter EB, Albrecht RA, Buschle KN, Chen YQ, Claeys C, Dickey M, Dugan HL, Ermler ME, Freeman D, Gao M, Gast C, Guthmiller JJ, Hai R, Henry C, Lan LY, McNeal M, Palm AE, Shaw DG, Stamper CT, Sun W, Sutton V, Tepora ME, Wahid R, Wenzel H, Wohlbold TJ, Innis BL, García-Sastre A, Palese P, Krammer F. Bernstein DI, et al. Lancet Infect Dis. 2020 Jan;20(1):80-91. doi: 10.1016/S1473-3099(19)30393-7. Epub 2019 Oct 17. Lancet Infect Dis. 2020. PMID: 31630990 Free PMC article. Clinical Trial.
Clinical outcome measures following plasma exchange for MG exacerbation.
Raja SM, Howard JF Jr, Juel VC, Massey JM, Chopra M, Guptill JT. Raja SM, et al. Ann Clin Transl Neurol. 2019 Oct;6(10):2114-2119. doi: 10.1002/acn3.50901. Epub 2019 Sep 27. Ann Clin Transl Neurol. 2019. PMID: 31560178 Free PMC article. Clinical Trial.
32 results