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Page 1
Lac-Phe mediates the effects of metformin on food intake and body weight.
Xiao S, Li VL, Lyu X, Chen X, Wei W, Abbasi F, Knowles JW, Tung AS, Deng S, Tiwari G, Shi X, Zheng S, Farrell L, Chen ZZ, Taylor KD, Guo X, Goodarzi MO, Wood AC, Chen YI, Lange LA, Rich SS, Rotter JI, Clish CB, Tahir UA, Gerszten RE, Benson MD, Long JZ. Xiao S, et al. Nat Metab. 2024 Apr;6(4):659-669. doi: 10.1038/s42255-024-00999-9. Epub 2024 Mar 18. Nat Metab. 2024. PMID: 38499766
Metabolomic epidemiology offers insights into disease aetiology.
Fuller H, Zhu Y, Nicholas J, Chatelaine HA, Drzymalla EM, Sarvestani AK, Julián-Serrano S, Tahir UA, Sinnott-Armstrong N, Raffield LM, Rahnavard A, Hua X, Shutta KH, Darst BF. Fuller H, et al. Nat Metab. 2023 Oct;5(10):1656-1672. doi: 10.1038/s42255-023-00903-x. Epub 2023 Oct 23. Nat Metab. 2023. PMID: 37872285 Review.
Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.
Feofanova EV, Brown MR, Alkis T, Manuel AM, Li X, Tahir UA, Li Z, Mendez KM, Kelly RS, Qi Q, Chen H, Larson MG, Lemaitre RN, Morrison AC, Grieser C, Wong KE, Gerszten RE, Zhao Z, Lasky-Su J; NHLBI Trans-Omics for Precision Medicine (TOPMed); Yu B. Feofanova EV, et al. Nat Commun. 2023 May 30;14(1):3111. doi: 10.1038/s41467-023-38800-2. Nat Commun. 2023. PMID: 37253714 Free PMC article.
CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels.
Tanzo JT, Li VL, Wiggenhorn AL, Moya-Garzon MD, Wei W, Lyu X, Dong W, Tahir UA, Chen ZZ, Cruz DE, Deng S, Shi X, Zheng S, Guo Y, Sims M, Abu-Remaileh M, Wilson JG, Gerszten RE, Long JZ, Benson MD. Tanzo JT, et al. J Biol Chem. 2023 Jun;299(6):104764. doi: 10.1016/j.jbc.2023.104764. Epub 2023 Apr 28. J Biol Chem. 2023. PMID: 37121548 Free PMC article.
Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations.
Robbins JM, Rao P, Deng S, Keyes MJ, Tahir UA, Katz DH, Beltran PMJ, Marchildon F, Barber JL, Peterson B, Gao Y, Correa A, Wilson JG, Smith JG, Cohen P, Ross R, Bouchard C, Sarzynski MA, Gerszten RE. Robbins JM, et al. JCI Insight. 2023 Apr 10;8(7):e165867. doi: 10.1172/jci.insight.165867. JCI Insight. 2023. PMID: 37036009 Free PMC article.
An atlas of genetic scores to predict multi-omic traits.
Xu Y, Ritchie SC, Liang Y, Timmers PRHJ, Pietzner M, Lannelongue L, Lambert SA, Tahir UA, May-Wilson S, Foguet C, Johansson Å, Surendran P, Nath AP, Persyn E, Peters JE, Oliver-Williams C, Deng S, Prins B, Luan J, Bomba L, Soranzo N, Di Angelantonio E, Pirastu N, Tai ES, van Dam RM, Parkinson H, Davenport EE, Paul DS, Yau C, Gerszten RE, Mälarstig A, Danesh J, Sim X, Langenberg C, Wilson JF, Butterworth AS, Inouye M. Xu Y, et al. Nature. 2023 Apr;616(7955):123-131. doi: 10.1038/s41586-023-05844-9. Epub 2023 Mar 29. Nature. 2023. PMID: 36991119 Free PMC article.
Protein Markers of Diabetes Discovered in an African American Cohort.
Chen ZZ, Gao Y, Keyes MJ, Deng S, Mi M, Farrell LA, Shen D, Tahir UA, Cruz DE, Ngo D, Benson MD, Robbins JM, Correa A, Wilson JG, Gerszten RE. Chen ZZ, et al. Diabetes. 2023 Apr 1;72(4):532-543. doi: 10.2337/db22-0710. Diabetes. 2023. PMID: 36630488 Free PMC article.
Nontargeted and Targeted Metabolomic Profiling Reveals Novel Metabolite Biomarkers of Incident Diabetes in African Americans.
Chen ZZ, Pacheco JA, Gao Y, Deng S, Peterson B, Shi X, Zheng S, Tahir UA, Katz DH, Cruz DE, Ngo D, Benson MD, Robbins JM, Guo X, Del Rocio Sevilla Gonzalez M, Manning A, Correa A, Meigs JB, Taylor KD, Rich SS, Goodarzi MO, Rotter JI, Wilson JG, Clish CB, Gerszten RE. Chen ZZ, et al. Diabetes. 2022 Nov 1;71(11):2426-2437. doi: 10.2337/db22-0033. Diabetes. 2022. PMID: 35998269 Free PMC article.
Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.
Tahir UA, Katz DH, Avila-Pachecho J, Bick AG, Pampana A, Robbins JM, Yu Z, Chen ZZ, Benson MD, Cruz DE, Ngo D, Deng S, Shi X, Zheng S, Eisman AS, Farrell L, Hall ME, Correa A, Tracy RP, Durda P, Taylor KD, Liu Y, Johnson WC, Guo X, Yao J, Chen YI, Manichaikul AW, Ruberg FL, Blaner WS, Jain D; NHLBI Trans-Omics for Precision Medicine 1 Consortium; Bouchard C, Sarzynski MA, Rich SS, Rotter JI, Wang TJ, Wilson JG, Clish CB, Natarajan P, Gerszten RE. Tahir UA, et al. Nat Commun. 2022 Aug 22;13(1):4923. doi: 10.1038/s41467-022-32275-3. Nat Commun. 2022. PMID: 35995766 Free PMC article.