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Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets.
Nacev BA, Sanchez-Vega F, Smith SA, Antonescu CR, Rosenbaum E, Shi H, Tang C, Socci ND, Rana S, Gularte-Mérida R, Zehir A, Gounder MM, Bowler TG, Luthra A, Jadeja B, Okada A, Strong JA, Stoller J, Chan JE, Chi P, D'Angelo SP, Dickson MA, Kelly CM, Keohan ML, Movva S, Thornton K, Meyers PA, Wexler LH, Slotkin EK, Glade Bender JL, Shukla NN, Hensley ML, Healey JH, La Quaglia MP, Alektiar KM, Crago AM, Yoon SS, Untch BR, Chiang S, Agaram NP, Hameed MR, Berger MF, Solit DB, Schultz N, Ladanyi M, Singer S, Tap WD. Nacev BA, et al. Nat Commun. 2022 Jun 15;13(1):3405. doi: 10.1038/s41467-022-30453-x. Nat Commun. 2022. PMID: 35705560 Free PMC article.
Oncohistone mutations enhance chromatin remodeling and alter cell fates.
Bagert JD, Mitchener MM, Patriotis AL, Dul BE, Wojcik F, Nacev BA, Feng L, Allis CD, Muir TW. Bagert JD, et al. Nat Chem Biol. 2021 Apr;17(4):403-411. doi: 10.1038/s41589-021-00738-1. Epub 2021 Mar 1. Nat Chem Biol. 2021. PMID: 33649601 Free PMC article.
The epigenomics of sarcoma.
Nacev BA, Jones KB, Intlekofer AM, Yu JSE, Allis CD, Tap WD, Ladanyi M, Nielsen TO. Nacev BA, et al. Nat Rev Cancer. 2020 Oct;20(10):608-623. doi: 10.1038/s41568-020-0288-4. Epub 2020 Aug 11. Nat Rev Cancer. 2020. PMID: 32782366 Free PMC article. Review.