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De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8.
Nat Commun. 2023 Sep 13;14(1):5660. doi: 10.1038/s41467-023-41272-z.
Nat Commun. 2023.
PMID: 37704610
Free PMC article.
De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8.
Roy A, Shi L, Chang A, Dong X, Fernandez A, Kraft JC, Li J, Le VQ, Winegar RV, Cherf GM, Slocum D, Daniel Poulson P, Casper GE, Vallecillo-Zúniga ML, Valdoz JC, Miranda MC, Bai H, Kipnis Y, Olshefsky A, Priya T, Carter L, Ravichandran R, Chow CM, Johnson MR, Cheng S, Smith M, Overed-Sayer C, Finch DK, Lowe D, Bera AK, Matute-Bello G, Birkland TP, DiMaio F, Raghu G, Cochran JR, Stewart LJ, Campbell MG, Van Ry PM, Springer T, Baker D.
Roy A, et al.
bioRxiv [Preprint]. 2023 Jun 12:2023.06.12.544624. doi: 10.1101/2023.06.12.544624.
bioRxiv. 2023.
PMID: 37398153
Free PMC article.
Updated.
Preprint.
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A specialized integrin-binding motif enables proTGF-β2 activation by integrin αVβ6 but not αVβ8.
Le VQ, Zhao B, Ramesh S, Toohey C, DeCosta A, Mintseris J, Liu X, Gygi S, Springer TA.
Le VQ, et al.
Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2304874120. doi: 10.1073/pnas.2304874120. Epub 2023 Jun 6.
Proc Natl Acad Sci U S A. 2023.
PMID: 37279271
Free PMC article.
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