Küpper JH - Search Results

1

Real time monitoring of oxygen uptake of hepatocytes in a microreactor using optical microsensors.

Gehre C, Flechner M, Kammerer S, Küpper JH, Coleman CD, Püschel GP, Uhlig K, Duschl C. Gehre C, et al. Among authors: kupper jh. Sci Rep. 2020 Aug 13;10(1):13700. doi: 10.1038/s41598-020-70785-6. Sci Rep. 2020. PMID: 32792676 Free PMC article.

2

Primary-like human hepatocytes genetically engineered to obtain proliferation competence display hepatic differentiation characteristics in monolayer and organotypical spheroid cultures.

Herzog N, Hansen M, Miethbauer S, Schmidtke KU, Anderer U, Lupp A, Sperling S, Seehofer D, Damm G, Scheibner K, Küpper JH. Herzog N, et al. Among authors: kupper jh. Cell Biol Int. 2016 Mar;40(3):341-53. doi: 10.1002/cbin.10574. Epub 2016 Jan 18. Cell Biol Int. 2016. PMID: 26715207

3

ATP-based cell viability assay is superior to trypan blue exclusion and XTT assay in measuring cytotoxicity of anticancer drugs Taxol and Imatinib, and proteasome inhibitor MG-132 on human hepatoma cell line HepG2.

Nowak E, Kammerer S, Küpper JH. Nowak E, et al. Among authors: kupper jh. Clin Hemorheol Microcirc. 2018;69(1-2):327-336. doi: 10.3233/CH-189120. Clin Hemorheol Microcirc. 2018. PMID: 29630545

4

Optimized protocol for induction of cytochrome P450 enzymes 1A2 and 3A4 in human primary-like hepatocyte cell strain HepaFH3 to study in vitro toxicology.

Kammerer S, Küpper JH. Kammerer S, et al. Among authors: kupper jh. Clin Hemorheol Microcirc. 2018;70(4):563-571. doi: 10.3233/CH-189321. Clin Hemorheol Microcirc. 2018. PMID: 30347615

5

Metabolic activity testing can underestimate acute drug cytotoxicity as revealed by HepG2 cell clones overexpressing cytochrome P450 2C19 and 3A4.

Steinbrecht S, König R, Schmidtke KU, Herzog N, Scheibner K, Krüger-Genge A, Jung F, Kammerer S, Küpper JH. Steinbrecht S, et al. Among authors: kupper jh. Toxicology. 2019 Jan 15;412:37-47. doi: 10.1016/j.tox.2018.11.008. Epub 2018 Nov 27. Toxicology. 2019. PMID: 30500380

6

Interactions of Alectinib with Human ATP-Binding Cassette Drug Efflux Transporters and Cytochrome P450 Biotransformation Enzymes: Effect on Pharmacokinetic Multidrug Resistance.

Hofman J, Sorf A, Vagiannis D, Sucha S, Novotna E, Kammerer S, Küpper JH, Ceckova M, Staud F. Hofman J, et al. Among authors: kupper jh. Drug Metab Dispos. 2019 Jul;47(7):699-709. doi: 10.1124/dmd.119.086975. Epub 2019 May 8. Drug Metab Dispos. 2019. PMID: 31068367

7

NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies.

Schulz C, Kammerer S, Küpper JH. Schulz C, et al. Among authors: kupper jh. Clin Hemorheol Microcirc. 2019;73(1):249-260. doi: 10.3233/CH-199226. Clin Hemorheol Microcirc. 2019. PMID: 31561354 Free PMC article.

8

Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes.

Hofman J, Sorf A, Vagiannis D, Sucha S, Kammerer S, Küpper JH, Chen S, Guo L, Ceckova M, Staud F. Hofman J, et al. Among authors: kupper jh. Mol Pharm. 2019 Nov 4;16(11):4436-4450. doi: 10.1021/acs.molpharmaceut.9b00361. Epub 2019 Oct 21. Mol Pharm. 2019. PMID: 31633365

9

HepG2-1A2 C2 and C7: Lentivirus vector-mediated stable and functional overexpression of cytochrome P450 1A2 in human hepatoblastoma cells.

Steinbrecht S, Pfeifer N, Herzog N, Katzenberger N, Schulz C, Kammerer S, Küpper JH. Steinbrecht S, et al. Among authors: kupper jh. Toxicol Lett. 2020 Feb 1;319:155-159. doi: 10.1016/j.toxlet.2019.11.006. Epub 2019 Nov 6. Toxicol Lett. 2020. PMID: 31706005

10

Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme.

Vagiannis D, Novotna E, Skarka A, Kammerer S, Küpper JH, Chen S, Guo L, Staud F, Hofman J. Vagiannis D, et al. Among authors: kupper jh. Cancers (Basel). 2020 Mar 28;12(4):813. doi: 10.3390/cancers12040813. Cancers (Basel). 2020. PMID: 32231067 Free PMC article.

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