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Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease.
de Freitas Silva M, Tardelli Lima E, Pruccoli L, Castro NG, Guimarães MJR, M R da Silva F, Fonseca Nadur N, de Azevedo LL, Kümmerle AE, Guedes IA, Dardenne LE, Gontijo VS, Tarozzi A, Viegas C. de Freitas Silva M, et al. Among authors: kummerle ae. Molecules. 2020 Jul 10;25(14):3165. doi: 10.3390/molecules25143165. Molecules. 2020. PMID: 32664425 Free PMC article.
Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation.
Cristancho Ortiz CJ, de Freitas Silva M, Pruccoli L, Fonseca Nadur N, de Azevedo LL, Kümmerle AE, Guedes IA, Dardenne LE, Leomil Coelho LF, Guimarães MJ, da Silva FMR, Castro N, Gontijo VS, Rojas VCT, de Oliveira MK, Vilela FC, Giusti-Paiva A, Barbosa G, Lima LM, Pinheiro GB, Veras LG, Mortari MR, Tarozzi A, Viegas C Jr. Cristancho Ortiz CJ, et al. Among authors: kummerle ae. RSC Med Chem. 2022 Mar 17;13(5):568-584. doi: 10.1039/d1md00374g. eCollection 2022 May 25. RSC Med Chem. 2022. PMID: 35694691 Free PMC article.
Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant.
de Souza GA, da Silva SJ, Del Cistia CN, Pitasse-Santos P, Pires LO, Passos YM, Cordeiro Y, Cardoso CM, Castro RN, Sant'Anna CMR, Kümmerle AE. de Souza GA, et al. Among authors: kummerle ae. J Enzyme Inhib Med Chem. 2019 Dec;34(1):631-637. doi: 10.1080/14756366.2019.1571270. J Enzyme Inhib Med Chem. 2019. PMID: 30727776 Free PMC article.
Synthesis and Evaluation of Antiproliferative Activity, Topoisomerase IIα Inhibition, DNA Binding and Non-Clinical Toxicity of New Acridine-Thiosemicarbazone Derivatives.
Sousa G, de Almeida MCF, Lócio LL, Dos Santos VL, Bezerra DP, Silva VR, de Almeida SMV, Simon A, Honório TDS, Cabral LM, Castro RN, de Moura RO, Kümmerle AE. Sousa G, et al. Among authors: kummerle ae. Pharmaceuticals (Basel). 2022 Sep 2;15(9):1098. doi: 10.3390/ph15091098. Pharmaceuticals (Basel). 2022. PMID: 36145320 Free PMC article.
38 results