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Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation.
Cell Rep. 2022 Aug 9;40(6):111175. doi: 10.1016/j.celrep.2022.111175.
Cell Rep. 2022.
PMID: 35947953
Free PMC article.
Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα.
Wunderle L, Knopf JD, Kühnle N, Morlé A, Hehn B, Adrain C, Strisovsky K, Freeman M, Lemberg MK.
Wunderle L, et al. Among authors: kuhnle n.
Sci Rep. 2016 Jun 6;6:27342. doi: 10.1038/srep27342.
Sci Rep. 2016.
PMID: 27264103
Free PMC article.
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Intramembrane proteolysis at a glance: from signalling to protein degradation.
Kühnle N, Dederer V, Lemberg MK.
Kühnle N, et al.
J Cell Sci. 2019 Aug 15;132(16):jcs217745. doi: 10.1242/jcs.217745.
J Cell Sci. 2019.
PMID: 31416853
Review.
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Intramembrane protease RHBDL4 cleaves oligosaccharyltransferase subunits to target them for ER-associated degradation.
Knopf JD, Landscheidt N, Pegg CL, Schulz BL, Kühnle N, Chao CW, Huck S, Lemberg MK.
Knopf JD, et al. Among authors: kuhnle n.
J Cell Sci. 2020 Mar 26;133(6):jcs243790. doi: 10.1242/jcs.243790.
J Cell Sci. 2020.
PMID: 32005703
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RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling.
Knopf JD, Steigleder SS, Korn F, Kühnle N, Badenes M, Tauber M, Theobald SJ, Rybniker J, Adrain C, Lemberg MK.
Knopf JD, et al. Among authors: kuhnle n.
Nat Commun. 2024 Mar 7;15(1):1528. doi: 10.1038/s41467-024-45615-2.
Nat Commun. 2024.
PMID: 38453906
Free PMC article.
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