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Therapeutic effect of IVIG on inflammatory arthritis in mice is dependent on the Fc portion and independent of sialylation or basophils.
Campbell IK, Miescher S, Branch DR, Mott PJ, Lazarus AH, Han D, Maraskovsky E, Zuercher AW, Neschadim A, Leontyev D, McKenzie BS, Käsermann F. Campbell IK, et al. Among authors: kasermann f. J Immunol. 2014 Jun 1;192(11):5031-8. doi: 10.4049/jimmunol.1301611. Epub 2014 Apr 23. J Immunol. 2014. PMID: 24760152 Free PMC article.
IVIG in autoimmune disease - Potential next generation biologics.
Zuercher AW, Spirig R, Baz Morelli A, Käsermann F. Zuercher AW, et al. Among authors: kasermann f. Autoimmun Rev. 2016 Aug;15(8):781-5. doi: 10.1016/j.autrev.2016.03.018. Epub 2016 Mar 25. Autoimmun Rev. 2016. PMID: 27019051 Review.
IVIG regulates the survival of human but not mouse neutrophils.
Schneider C, Wicki S, Graeter S, Timcheva TM, Keller CW, Quast I, Leontyev D, Djoumerska-Alexieva IK, Käsermann F, Jakob SM, Dimitrova PA, Branch DR, Cummings RD, Lünemann JD, Kaufmann T, Simon HU, von Gunten S. Schneider C, et al. Among authors: kasermann f. Sci Rep. 2017 May 2;7(1):1296. doi: 10.1038/s41598-017-01404-0. Sci Rep. 2017. PMID: 28465620 Free PMC article.
rIgG1 Fc Hexamer Inhibits Antibody-Mediated Autoimmune Disease via Effects on Complement and FcγRs.
Spirig R, Campbell IK, Koernig S, Chen CG, Lewis BJB, Butcher R, Muir I, Taylor S, Chia J, Leong D, Simmonds J, Scotney P, Schmidt P, Fabri L, Hofmann A, Jordi M, Spycher MO, Cattepoel S, Brasseit J, Panousis C, Rowe T, Branch DR, Baz Morelli A, Käsermann F, Zuercher AW. Spirig R, et al. Among authors: kasermann f. J Immunol. 2018 Apr 15;200(8):2542-2553. doi: 10.4049/jimmunol.1701171. Epub 2018 Mar 12. J Immunol. 2018. PMID: 29531170 Free PMC article.
Next-generation Fc receptor-targeting biologics for autoimmune diseases.
Zuercher AW, Spirig R, Baz Morelli A, Rowe T, Käsermann F. Zuercher AW, et al. Among authors: kasermann f. Autoimmun Rev. 2019 Oct;18(10):102366. doi: 10.1016/j.autrev.2019.102366. Epub 2019 Aug 9. Autoimmun Rev. 2019. PMID: 31404703 Free article. Review.
Using the K/BxN mouse model of endogenous, chronic, rheumatoid arthritis for the evaluation of potential immunoglobulin-based therapeutic agents, including IVIg and Fc-μTP-L309C, a recombinant IgG1 Fc hexamer.
Lewis BJB, Ville J, Blacquiere M, Cen S, Spirig R, Zuercher AW, Käsermann F, Branch DR. Lewis BJB, et al. Among authors: kasermann f. BMC Immunol. 2019 Dec 4;20(1):44. doi: 10.1186/s12865-019-0328-6. BMC Immunol. 2019. PMID: 31801459 Free PMC article.
36 results