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Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid.
Justinova Z, Mascia P, Wu HQ, Secci ME, Redhi GH, Panlilio LV, Scherma M, Barnes C, Parashos A, Zara T, Fratta W, Solinas M, Pistis M, Bergman J, Kangas BD, Ferré S, Tanda G, Schwarcz R, Goldberg SR. Justinova Z, et al. Nat Neurosci. 2013 Nov;16(11):1652-61. doi: 10.1038/nn.3540. Epub 2013 Oct 13. Nat Neurosci. 2013. PMID: 24121737 Free PMC article.
Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids.
Carriba P, Ortiz O, Patkar K, Justinova Z, Stroik J, Themann A, Müller C, Woods AS, Hope BT, Ciruela F, Casadó V, Canela EI, Lluis C, Goldberg SR, Moratalla R, Franco R, Ferré S. Carriba P, et al. Among authors: justinova z. Neuropsychopharmacology. 2007 Nov;32(11):2249-59. doi: 10.1038/sj.npp.1301375. Epub 2007 Mar 14. Neuropsychopharmacology. 2007. PMID: 17356572
Astrocytic Mechanisms Involving Kynurenic Acid Control Δ9-Tetrahydrocannabinol-Induced Increases in Glutamate Release in Brain Reward-Processing Areas.
Secci ME, Mascia P, Sagheddu C, Beggiato S, Melis M, Borelli AC, Tomasini MC, Panlilio LV, Schindler CW, Tanda G, Ferré S, Bradberry CW, Ferraro L, Pistis M, Goldberg SR, Schwarcz R, Justinova Z. Secci ME, et al. Among authors: justinova z. Mol Neurobiol. 2019 May;56(5):3563-3575. doi: 10.1007/s12035-018-1319-y. Epub 2018 Aug 27. Mol Neurobiol. 2019. PMID: 30151725 Free PMC article.
65 results