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BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor.
Meibom D, Wasnaire P, Beyer K, Broehl A, Cancho-Grande Y, Elowe N, Henninger K, Johannes S, Jungmann N, Krainz T, Lindner N, Maassen S, MacDonald B, Menshykau D, Mittendorf J, Sanchez G, Schaefer M, Stefan E, Torge A, Xing Y, Zubov D. Meibom D, et al. Among authors: jungmann n. J Med Chem. 2024 Feb 22;67(4):2907-2940. doi: 10.1021/acs.jmedchem.3c02036. Epub 2024 Feb 13. J Med Chem. 2024. PMID: 38348661 Free PMC article.
Applied physiologically-based pharmacokinetic modeling to assess uridine diphosphate-glucuronosyltransferase-mediated drug-drug interactions for Vericiguat.
Frechen S, Ince I, Dallmann A, Gerisch M, Jungmann NA, Becker C, Lobmeyer M, Trujillo ME, Xu S, Burghaus R, Meyer M. Frechen S, et al. Among authors: jungmann na. CPT Pharmacometrics Syst Pharmacol. 2024 Jan;13(1):79-92. doi: 10.1002/psp4.13059. Epub 2023 Oct 12. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 37794724 Free PMC article.
Observing many researchers using the same data and hypothesis reveals a hidden universe of uncertainty.
Breznau N, Rinke EM, Wuttke A, Nguyen HHV, Adem M, Adriaans J, Alvarez-Benjumea A, Andersen HK, Auer D, Azevedo F, Bahnsen O, Balzer D, Bauer G, Bauer PC, Baumann M, Baute S, Benoit V, Bernauer J, Berning C, Berthold A, Bethke FS, Biegert T, Blinzler K, Blumenberg JN, Bobzien L, Bohman A, Bol T, Bostic A, Brzozowska Z, Burgdorf K, Burger K, Busch KB, Carlos-Castillo J, Chan N, Christmann P, Connelly R, Czymara CS, Damian E, Ecker A, Edelmann A, Eger MA, Ellerbrock S, Forke A, Forster A, Gaasendam C, Gavras K, Gayle V, Gessler T, Gnambs T, Godefroidt A, Grömping M, Groß M, Gruber S, Gummer T, Hadjar A, Heisig JP, Hellmeier S, Heyne S, Hirsch M, Hjerm M, Hochman O, Hövermann A, Hunger S, Hunkler C, Huth N, Ignácz ZS, Jacobs L, Jacobsen J, Jaeger B, Jungkunz S, Jungmann N, Kauff M, Kleinert M, Klinger J, Kolb JP, Kołczyńska M, Kuk J, Kunißen K, Kurti Sinatra D, Langenkamp A, Lersch PM, Löbel LM, Lutscher P, Mader M, Madia JE, Malancu N, Maldonado L, Marahrens H, Martin N, Martinez P, Mayerl J, Mayorga OJ, McManus P, McWagner K, Meeusen C, Meierrieks D, Mellon J, Merhout F, Merk S, Meyer D, Micheli L, Mijs J, Moya C, Neunhoeffer M, Nüst D, Nygård O, Ochsenfeld F, Otte G, Pechen… See abstract for full author list ➔ Breznau N, et al. Among authors: jungmann n. Proc Natl Acad Sci U S A. 2022 Nov;119(44):e2203150119. doi: 10.1073/pnas.2203150119. Epub 2022 Oct 28. Proc Natl Acad Sci U S A. 2022. PMID: 36306328 Free PMC article.
Metabolism and Mass Balance of the Novel Nonsteroidal Androgen Receptor Inhibitor Darolutamide in Humans.
Taavitsainen P, Prien O, Kähkönen M, Niehues M, Korjamo T, Denner K, Nykänen P, Vuorela A, Jungmann NA, von Bühler CJ, Koskinen M, Zurth C, Gieschen H. Taavitsainen P, et al. Among authors: jungmann na. Drug Metab Dispos. 2021 Jun;49(6):420-433. doi: 10.1124/dmd.120.000309. Epub 2021 Mar 30. Drug Metab Dispos. 2021. PMID: 33785516 Clinical Trial.
The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides.
Wiebach V, Mainz A, Siegert MJ, Jungmann NA, Lesquame G, Tirat S, Dreux-Zigha A, Aszodi J, Le Beller D, Süssmuth RD. Wiebach V, et al. Among authors: jungmann na. Nat Chem Biol. 2018 Jul;14(7):652-654. doi: 10.1038/s41589-018-0068-6. Epub 2018 Jun 18. Nat Chem Biol. 2018. PMID: 29915235
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