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Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin.
Sicking M, Živná M, Bhadra P, Barešová V, Tirincsi A, Hadzibeganovic D, Hodaňová K, Vyleťal P, Sovová J, Jedličková I, Jung M, Bell T, Helms V, Bleyer AJ, Kmoch S, Cavalié A, Lang S. Sicking M, et al. Among authors: jung m. Life Sci Alliance. 2022 Jan 21;5(4):e202101150. doi: 10.26508/lsa.202101150. Print 2022 Apr. Life Sci Alliance. 2022. PMID: 35064074 Free PMC article.
Sec61 complexes form ubiquitous ER Ca2+ leak channels.
Lang S, Erdmann F, Jung M, Wagner R, Cavalie A, Zimmermann R. Lang S, et al. Among authors: jung m. Channels (Austin). 2011 May-Jun;5(3):228-35. doi: 10.4161/chan.5.3.15314. Epub 2011 May 1. Channels (Austin). 2011. PMID: 21406962
BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER.
Schäuble N, Lang S, Jung M, Cappel S, Schorr S, Ulucan Ö, Linxweiler J, Dudek J, Blum R, Helms V, Paton AW, Paton JC, Cavalié A, Zimmermann R. Schäuble N, et al. Among authors: jung m. EMBO J. 2012 Aug 1;31(15):3282-96. doi: 10.1038/emboj.2012.189. Epub 2012 Jul 13. EMBO J. 2012. PMID: 22796945 Free PMC article.
Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells.
Linxweiler M, Schorr S, Schäuble N, Jung M, Linxweiler J, Langer F, Schäfers HJ, Cavalié A, Zimmermann R, Greiner M. Linxweiler M, et al. Among authors: jung m. BMC Cancer. 2013 Dec 5;13:574. doi: 10.1186/1471-2407-13-574. BMC Cancer. 2013. PMID: 24304694 Free PMC article.
Protein transport into the human endoplasmic reticulum.
Dudek J, Pfeffer S, Lee PH, Jung M, Cavalié A, Helms V, Förster F, Zimmermann R. Dudek J, et al. Among authors: jung m. J Mol Biol. 2015 Mar 27;427(6 Pt A):1159-75. doi: 10.1016/j.jmb.2014.06.011. Epub 2014 Jun 23. J Mol Biol. 2015. PMID: 24968227 Review.
Co-chaperone Specificity in Gating of the Polypeptide Conducting Channel in the Membrane of the Human Endoplasmic Reticulum.
Schorr S, Klein MC, Gamayun I, Melnyk A, Jung M, Schäuble N, Wang Q, Hemmis B, Bochen F, Greiner M, Lampel P, Urban SK, Hassdenteufel S, Dudek J, Chen XZ, Wagner R, Cavalié A, Zimmermann R. Schorr S, et al. Among authors: jung m. J Biol Chem. 2015 Jul 24;290(30):18621-35. doi: 10.1074/jbc.M115.636639. Epub 2015 Jun 17. J Biol Chem. 2015. PMID: 26085089 Free PMC article.
5,366 results