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Metabolic Response to XD14 Treatment in Human Breast Cancer Cell Line MCF-7.
Pan D, Kather M, Willmann L, Schlimpert M, Bauer C, Lagies S, Schmidtkunz K, Eisenhardt SU, Jung M, Günther S, Kammerer B. Pan D, et al. Among authors: jung m. Int J Mol Sci. 2016 Oct 24;17(10):1772. doi: 10.3390/ijms17101772. Int J Mol Sci. 2016. PMID: 27783056 Free PMC article.
4-Acyl pyrroles: mimicking acetylated lysines in histone code reading.
Lucas X, Wohlwend D, Hügle M, Schmidtkunz K, Gerhardt S, Schüle R, Jung M, Einsle O, Günther S. Lucas X, et al. Among authors: jung m. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9. doi: 10.1002/anie.201307652. Epub 2013 Nov 24. Angew Chem Int Ed Engl. 2013. PMID: 24272870 No abstract available.
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M. Rumpf T, et al. Among authors: jung m. Nat Commun. 2015 Feb 12;6:6263. doi: 10.1038/ncomms7263. Nat Commun. 2015. PMID: 25672491 Free PMC article.
Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.
Wagner T, Greschik H, Burgahn T, Schmidtkunz K, Schott AK, McMillan J, Baranauskienė L, Xiong Y, Fedorov O, Jin J, Oppermann U, Matulis D, Schüle R, Jung M. Wagner T, et al. Among authors: jung m. Nucleic Acids Res. 2016 May 19;44(9):e88. doi: 10.1093/nar/gkw089. Epub 2016 Feb 17. Nucleic Acids Res. 2016. PMID: 26893353 Free PMC article.
Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).
Ostrovskyi D, Rumpf T, Eib J, Lumbroso A, Slynko I, Klaeger S, Heinzlmeir S, Forster M, Gehringer M, Pfaffenrot E, Bauer SM, Schmidtkunz K, Wenzler S, Metzger E, Kuster B, Laufer S, Schüle R, Sippl W, Breit B, Jung M. Ostrovskyi D, et al. Among authors: jung m. Future Med Chem. 2016 Sep;8(13):1537-51. doi: 10.4155/fmc-2016-0132. Epub 2016 Aug 30. Future Med Chem. 2016. PMID: 27572962
Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Hügle M, Lucas X, Ostrovskyi D, Regenass P, Gerhardt S, Einsle O, Hau M, Jung M, Breit B, Günther S, Wohlwend D. Hügle M, et al. Among authors: jung m. Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12476-12480. doi: 10.1002/anie.201705516. Epub 2017 Sep 7. Angew Chem Int Ed Engl. 2017. PMID: 28766825
Structure-Activity Relationship of Propargylamine-Based HDAC Inhibitors.
Wünsch M, Senger J, Schultheisz P, Schwarzbich S, Schmidtkunz K, Michalek C, Klaß M, Goskowitz S, Borchert P, Praetorius L, Sippl W, Jung M, Sewald N. Wünsch M, et al. Among authors: jung m. ChemMedChem. 2017 Dec 19;12(24):2044-2053. doi: 10.1002/cmdc.201700550. Epub 2017 Nov 30. ChemMedChem. 2017. PMID: 29120081
5,366 results