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Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease.
Sugiyama MG, Cui H, Redka DS, Karimzadeh M, Rujas E, Maan H, Hayat S, Cheung K, Misra R, McPhee JB, Viirre RD, Haller A, Botelho RJ, Karshafian R, Sabatinos SA, Fairn GD, Madani Tonekaboni SA, Windemuth A, Julien JP, Shahani V, MacKinnon SS, Wang B, Antonescu CN. Sugiyama MG, et al. Among authors: julien jp. Sci Rep. 2021 Dec 2;11(1):23315. doi: 10.1038/s41598-021-02432-7. Sci Rep. 2021. PMID: 34857794 Free PMC article.
Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments.
Rujas E, Insausti S, Leaman DP, Carravilla P, González-Resines S, Monceaux V, Sánchez-Eugenia R, García-Porras M, Iloro I, Zhang L, Elortza F, Julien JP, Saéz-Cirión A, Zwick MB, Eggeling C, Ojida A, Domene C, Caaveiro JMM, Nieva JL. Rujas E, et al. Among authors: julien jp. Cell Rep. 2020 Aug 18;32(7):108037. doi: 10.1016/j.celrep.2020.108037. Cell Rep. 2020. PMID: 32814041 Free PMC article.
Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers.
Rujas E, Kucharska I, Tan YZ, Benlekbir S, Cui H, Zhao T, Wasney GA, Budylowski P, Guvenc F, Newton JC, Sicard T, Semesi A, Muthuraman K, Nouanesengsy A, Aschner CB, Prieto K, Bueler SA, Youssef S, Liao-Chan S, Glanville J, Christie-Holmes N, Mubareka S, Gray-Owen SD, Rubinstein JL, Treanor B, Julien JP. Rujas E, et al. Among authors: julien jp. Nat Commun. 2021 Jun 16;12(1):3661. doi: 10.1038/s41467-021-23825-2. Nat Commun. 2021. PMID: 34135340 Free PMC article.
Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile.
Rujas E, Leaman DP, Insausti S, Carravilla P, García-Porras M, Largo E, Morillo I, Sánchez-Eugenia R, Zhang L, Cui H, Iloro I, Elortza F, Julien JP, Eggeling C, Zwick MB, Caaveiro JMM, Nieva JL. Rujas E, et al. Among authors: julien jp. iScience. 2021 Aug 17;24(9):102987. doi: 10.1016/j.isci.2021.102987. eCollection 2021 Sep 24. iScience. 2021. PMID: 34505005 Free PMC article.
Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice.
Mabrouk MT, Chiem K, Rujas E, Huang WC, Jahagirdar D, Quinn B, Surendran Nair M, Nissly RH, Cavener VS, Boyle NR, Sornberger TA, Kuchipudi SV, Ortega J, Julien JP, Martinez-Sobrido L, Lovell J. Mabrouk MT, et al. Among authors: julien jp. Sci Adv. 2021 Dec 3;7(49):eabj1476. doi: 10.1126/sciadv.abj1476. Epub 2021 Dec 1. Sci Adv. 2021. PMID: 34851667 Free PMC article.
Engineering pan-HIV-1 neutralization potency through multispecific antibody avidity.
Rujas E, Cui H, Burnie J, Aschner CB, Zhao T, Insausti S, Muthuraman K, Semesi A, Ophel J, Nieva JL, Seaman MS, Guzzo C, Treanor B, Julien JP. Rujas E, et al. Among authors: julien jp. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2112887119. doi: 10.1073/pnas.2112887119. Proc Natl Acad Sci U S A. 2022. PMID: 35064083 Free PMC article.
Modular adjuvant-free pan-HLA-DR-immunotargeting subunit vaccine against SARS-CoV-2 elicits broad sarbecovirus-neutralizing antibody responses.
Kassardjian A, Sun E, Sookhoo J, Muthuraman K, Boligan KF, Kucharska I, Rujas E, Jetha A, Branch DR, Babiuk S, Barber B, Julien JP. Kassardjian A, et al. Among authors: julien jp. Cell Rep. 2023 Apr 25;42(4):112391. doi: 10.1016/j.celrep.2023.112391. Epub 2023 Apr 3. Cell Rep. 2023. PMID: 37053069 Free PMC article.
380 results