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AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington's Disease Minipig Model.
Evers MM, Miniarikova J, Juhas S, Vallès A, Bohuslavova B, Juhasova J, Skalnikova HK, Vodicka P, Valekova I, Brouwers C, Blits B, Lubelski J, Kovarova H, Ellederova Z, van Deventer SJ, Petry H, Motlik J, Konstantinova P. Evers MM, et al. Among authors: juhas s. Mol Ther. 2018 Sep 5;26(9):2163-2177. doi: 10.1016/j.ymthe.2018.06.021. Epub 2018 Jun 25. Mol Ther. 2018. PMID: 30007561 Free PMC article.
Pig models of neurodegenerative disorders: Utilization in cell replacement-based preclinical safety and efficacy studies.
Dolezalova D, Hruska-Plochan M, Bjarkam CR, Sørensen JC, Cunningham M, Weingarten D, Ciacci JD, Juhas S, Juhasova J, Motlik J, Hefferan MP, Hazel T, Johe K, Carromeu C, Muotri A, Bui J, Strnadel J, Marsala M. Dolezalova D, et al. Among authors: juhas s. J Comp Neurol. 2014 Aug 15;522(12):2784-801. doi: 10.1002/cne.23575. Epub 2014 Apr 12. J Comp Neurol. 2014. PMID: 24610493 Review.
A transgenic minipig model of Huntington's Disease.
Baxa M, Hruska-Plochan M, Juhas S, Vodicka P, Pavlok A, Juhasova J, Miyanohara A, Nejime T, Klima J, Macakova M, Marsala S, Weiss A, Kubickova S, Musilova P, Vrtel R, Sontag EM, Thompson LM, Schier J, Hansikova H, Howland DS, Cattaneo E, DiFiglia M, Marsala M, Motlik J. Baxa M, et al. Among authors: juhas s. J Huntingtons Dis. 2013;2(1):47-68. doi: 10.3233/JHD-130001. J Huntingtons Dis. 2013. PMID: 25063429
Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars.
Macakova M, Bohuslavova B, Vochozkova P, Pavlok A, Sedlackova M, Vidinska D, Vochyanova K, Liskova I, Valekova I, Baxa M, Ellederova Z, Klima J, Juhas S, Juhasova J, Klouckova J, Haluzik M, Klempir J, Hansikova H, Spacilova J, Collins R, Blumenthal I, Talkowski M, Gusella JF, Howland DS, DiFiglia M, Motlik J. Macakova M, et al. Among authors: juhas s. Neurodegener Dis. 2016;16(3-4):245-59. doi: 10.1159/000443665. Epub 2016 Mar 10. Neurodegener Dis. 2016. PMID: 26959244
Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs.
Miyanohara A, Kamizato K, Juhas S, Juhasova J, Navarro M, Marsala S, Lukacova N, Hruska-Plochan M, Curtis E, Gabel B, Ciacci J, Ahrens ET, Kaspar BK, Cleveland D, Marsala M. Miyanohara A, et al. Among authors: juhas s. Mol Ther Methods Clin Dev. 2016 Jul 13;3:16046. doi: 10.1038/mtm.2016.46. eCollection 2016. Mol Ther Methods Clin Dev. 2016. PMID: 27462649 Free PMC article.
81 results