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Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.
Rotroff DM, Wetmore BA, Dix DJ, Ferguson SS, Clewell HJ, Houck KA, Lecluyse EL, Andersen ME, Judson RS, Smith CM, Sochaski MA, Kavlock RJ, Boellmann F, Martin MT, Reif DM, Wambaugh JF, Thomas RS. Rotroff DM, et al. Among authors: judson rs. Toxicol Sci. 2010 Oct;117(2):348-58. doi: 10.1093/toxsci/kfq220. Epub 2010 Jul 16. Toxicol Sci. 2010. PMID: 20639261 Free PMC article.
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.
Knudsen TB, Houck KA, Sipes NS, Singh AV, Judson RS, Martin MT, Weissman A, Kleinstreuer NC, Mortensen HM, Reif DM, Rabinowitz JR, Setzer RW, Richard AM, Dix DJ, Kavlock RJ. Knudsen TB, et al. Among authors: judson rs. Toxicology. 2011 Mar 28;282(1-2):1-15. doi: 10.1016/j.tox.2010.12.010. Epub 2011 Jan 18. Toxicology. 2011. PMID: 21251949
Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays.
Wetmore BA, Wambaugh JF, Ferguson SS, Li L, Clewell HJ 3rd, Judson RS, Freeman K, Bao W, Sochaski MA, Chu TM, Black MB, Healy E, Allen B, Andersen ME, Wolfinger RD, Thomas RS. Wetmore BA, et al. Among authors: judson rs. Toxicol Sci. 2013 Apr;132(2):327-46. doi: 10.1093/toxsci/kft012. Epub 2013 Jan 28. Toxicol Sci. 2013. PMID: 23358191
Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.
Wetmore BA, Wambaugh JF, Allen B, Ferguson SS, Sochaski MA, Setzer RW, Houck KA, Strope CL, Cantwell K, Judson RS, LeCluyse E, Clewell HJ, Thomas RS, Andersen ME. Wetmore BA, et al. Among authors: judson rs. Toxicol Sci. 2015 Nov;148(1):121-36. doi: 10.1093/toxsci/kfv171. Epub 2015 Aug 6. Toxicol Sci. 2015. PMID: 26251325 Free PMC article.
Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor.
Judson RS, Magpantay FM, Chickarmane V, Haskell C, Tania N, Taylor J, Xia M, Huang R, Rotroff DM, Filer DL, Houck KA, Martin MT, Sipes N, Richard AM, Mansouri K, Setzer RW, Knudsen TB, Crofton KM, Thomas RS. Judson RS, et al. Toxicol Sci. 2015 Nov;148(1):137-54. doi: 10.1093/toxsci/kfv168. Epub 2015 Aug 13. Toxicol Sci. 2015. PMID: 26272952 Free PMC article.
121 results