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Melatonin improves neuroplasticity by upregulating the growth-associated protein-43 (GAP-43) and NMDAR postsynaptic density-95 (PSD-95) proteins in cultured neurons exposed to glutamate excitotoxicity and in rats subjected to transient focal cerebral ischemia even during a long-term recovery period.
Juan WS, Huang SY, Chang CC, Hung YC, Lin YW, Chen TY, Lee AH, Lee AC, Wu TS, Lee EJ. Juan WS, et al. J Pineal Res. 2014 Mar;56(2):213-23. doi: 10.1111/jpi.12114. Epub 2014 Jan 13. J Pineal Res. 2014. PMID: 24350898