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A novel method to detect hPG80 (human circulating progastrin) in the blood.
Cappellini M, Flaceliere M, Saywell V, Soule J, Blanc E, Belouin F, Ortiz E, Canterel-Thouennon L, Poupeau S, Tigrett S, Vire B, Liaud P, Blairvacq M, Joubert D, Prieur A. Cappellini M, et al. Among authors: joubert d. Anal Methods. 2021 Oct 8;13(38):4468-4477. doi: 10.1039/d1ay00986a. Anal Methods. 2021. PMID: 34494619
The oncogenic and druggable hPG80 (Progastrin) is overexpressed in multiple cancers and detected in the blood of patients.
You B, Mercier F, Assenat E, Langlois-Jacques C, Glehen O, Soulé J, Payen L, Kepenekian V, Dupuy M, Belouin F, Morency E, Saywell V, Flacelière M, Elies P, Liaud P, Mazard T, Maucort-Boulch D, Tan W, Vire B, Villeneuve L, Ychou M, Kohli M, Joubert D, Prieur A. You B, et al. Among authors: joubert d. EBioMedicine. 2020 Jan;51:102574. doi: 10.1016/j.ebiom.2019.11.035. Epub 2019 Dec 24. EBioMedicine. 2020. PMID: 31877416 Free PMC article.
Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer.
Prieur A, Cappellini M, Habif G, Lefranc MP, Mazard T, Morency E, Pascussi JM, Flacelière M, Cahuzac N, Vire B, Dubuc B, Durochat A, Liaud P, Ollier J, Pfeiffer C, Poupeau S, Saywell V, Planque C, Assenat E, Bibeau F, Bourgaux JF, Pujol P, Sézeur A, Ychou M, Joubert D. Prieur A, et al. Among authors: joubert d. Clin Cancer Res. 2017 Sep 1;23(17):5267-5280. doi: 10.1158/1078-0432.CCR-17-0533. Epub 2017 Jun 9. Clin Cancer Res. 2017. PMID: 28600477
Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells.
Giraud J, Failla LM, Pascussi JM, Lagerqvist EL, Ollier J, Finetti P, Bertucci F, Ya C, Gasmi I, Bourgaux JF, Prudhomme M, Mazard T, Ait-Arsa I, Houhou L, Birnbaum D, Pélegrin A, Vincent C, Ryall JG, Joubert D, Pannequin J, Hollande F. Giraud J, et al. Among authors: joubert d. Cancer Res. 2016 Jun 15;76(12):3618-28. doi: 10.1158/0008-5472.CAN-15-1497. Epub 2016 May 4. Cancer Res. 2016. PMID: 27197176
Essential requirement for β-arrestin2 in mouse intestinal tumors with elevated Wnt signaling.
Bonnans C, Flacelière M, Grillet F, Dantec C, Desvignes JP, Pannequin J, Severac D, Dubois E, Bibeau F, Escriou V, Crespy P, Journot L, Hollande F, Joubert D. Bonnans C, et al. Among authors: joubert d. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3047-52. doi: 10.1073/pnas.1109457109. Epub 2012 Feb 6. Proc Natl Acad Sci U S A. 2012. PMID: 22315403 Free PMC article.
Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors.
Pannequin J, Delaunay N, Buchert M, Surrel F, Bourgaux JF, Ryan J, Boireau S, Coelho J, Pélegrin A, Singh P, Shulkes A, Yim M, Baldwin GS, Pignodel C, Lambeau G, Jay P, Joubert D, Hollande F. Pannequin J, et al. Among authors: joubert d. Gastroenterology. 2007 Nov;133(5):1554-68. doi: 10.1053/j.gastro.2007.08.023. Epub 2007 Oct 24. Gastroenterology. 2007. PMID: 17920061
178 results