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Page 1
Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.
Bakowski MA, Shiroodi RK, Liu R, Olejniczak J, Yang B, Gagaring K, Guo H, White PM, Chappell L, Debec A, Landmann F, Dubben B, Lenz F, Struever D, Ehrens A, Frohberger SJ, Sjoberg H, Pionnier N, Murphy E, Archer J, Steven A, Chunda VC, Fombad FF, Chounna PW, Njouendou AJ, Metuge HM, Ndzeshang BL, Gandjui NV, Akumtoh DN, Kwenti TDB, Woods AK, Joseph SB, Hull MV, Xiong W, Kuhen KL, Taylor MJ, Wanji S, Turner JD, Hübner MP, Hoerauf A, Chatterjee AK, Roland J, Tremblay MS, Schultz PG, Sullivan W, Chu XJ, Petrassi HM, McNamara CW. Bakowski MA, et al. Among authors: joseph sb. Sci Transl Med. 2019 May 8;11(491):eaav3523. doi: 10.1126/scitranslmed.aav3523. Sci Transl Med. 2019. PMID: 31068442
Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant.
Wang RE, Wang Y, Zhang Y, Gabrelow C, Zhang Y, Chi V, Fu Q, Luo X, Wang D, Joseph S, Johnson K, Chatterjee AK, Wright TM, Nguyen-Tran VT, Teijaro J, Theofilopoulos AN, Schultz PG, Wang F. Wang RE, et al. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11501-11506. doi: 10.1073/pnas.1612803113. Epub 2016 Sep 23. Proc Natl Acad Sci U S A. 2016. PMID: 27663736 Free PMC article.
The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis.
Janes J, Young ME, Chen E, Rogers NH, Burgstaller-Muehlbacher S, Hughes LD, Love MS, Hull MV, Kuhen KL, Woods AK, Joseph SB, Petrassi HM, McNamara CW, Tremblay MS, Su AI, Schultz PG, Chatterjee AK. Janes J, et al. Among authors: joseph sb. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10750-10755. doi: 10.1073/pnas.1810137115. Epub 2018 Oct 3. Proc Natl Acad Sci U S A. 2018. PMID: 30282735 Free PMC article.
Neratinib protects pancreatic beta cells in diabetes.
Ardestani A, Li S, Annamalai K, Lupse B, Geravandi S, Dobrowolski A, Yu S, Zhu S, Baguley TD, Surakattula M, Oetjen J, Hauberg-Lotte L, Herranz R, Awal S, Altenhofen D, Nguyen-Tran V, Joseph S, Schultz PG, Chatterjee AK, Rogers N, Tremblay MS, Shen W, Maedler K. Ardestani A, et al. Nat Commun. 2019 Nov 1;10(1):5015. doi: 10.1038/s41467-019-12880-5. Nat Commun. 2019. PMID: 31676778 Free PMC article.
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.
Chin EN, Yu C, Vartabedian VF, Jia Y, Kumar M, Gamo AM, Vernier W, Ali SH, Kissai M, Lazar DC, Nguyen N, Pereira LE, Benish B, Woods AK, Joseph SB, Chu A, Johnson KA, Sander PN, Martínez-Peña F, Hampton EN, Young TS, Wolan DW, Chatterjee AK, Schultz PG, Petrassi HM, Teijaro JR, Lairson LL. Chin EN, et al. Among authors: joseph sb. Science. 2020 Aug 21;369(6506):993-999. doi: 10.1126/science.abb4255. Science. 2020. PMID: 32820126
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions.
Bakowski MA, Beutler N, Wolff KC, Kirkpatrick MG, Chen E, Nguyen TH, Riva L, Shaabani N, Parren M, Ricketts J, Gupta AK, Pan K, Kuo P, Fuller M, Garcia E, Teijaro JR, Yang L, Sahoo D, Chi V, Huang E, Vargas N, Roberts AJ, Das S, Ghosh P, Woods AK, Joseph SB, Hull MV, Schultz PG, Burton DR, Chatterjee AK, McNamara CW, Rogers TF. Bakowski MA, et al. Among authors: joseph sb. Nat Commun. 2021 Jun 3;12(1):3309. doi: 10.1038/s41467-021-23328-0. Nat Commun. 2021. PMID: 34083527 Free PMC article.
A PSMA-targeted bispecific antibody for prostate cancer driven by a small-molecule targeting ligand.
Lee SC, Ma JSY, Kim MS, Laborda E, Choi SH, Hampton EN, Yun H, Nunez V, Muldong MT, Wu CN, Ma W, Kulidjian AA, Kane CJ, Klyushnichenko V, Woods AK, Joseph SB, Petrassi M, Wisler J, Li J, Jamieson CAM, Schultz PG, Kim CH, Young TS. Lee SC, et al. Among authors: joseph sb. Sci Adv. 2021 Aug 11;7(33):eabi8193. doi: 10.1126/sciadv.abi8193. Print 2021 Aug. Sci Adv. 2021. PMID: 34380625 Free PMC article.
Pharmacokinetics and Pharmacodynamics of Clofazimine for Treatment of Cryptosporidiosis.
Zhang CX, Love MS, McNamara CW, Chi V, Woods AK, Joseph S, Schaefer DA, Betzer DP, Riggs MW, Iroh Tam PY, Van Voorhis WC, Arnold SLM. Zhang CX, et al. Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0156021. doi: 10.1128/AAC.01560-21. Epub 2021 Nov 8. Antimicrob Agents Chemother. 2022. PMID: 34748385 Free PMC article.
A small molecule UPR modulator for diabetes identified by high throughput screening.
Marrocco V, Tran T, Zhu S, Choi SH, Gamo AM, Li S, Fu Q, Cunado MD, Roland J, Hull M, Nguyen-Tran V, Joseph S, Chatterjee AK, Rogers N, Tremblay MS, Shen W. Marrocco V, et al. Acta Pharm Sin B. 2021 Dec;11(12):3983-3993. doi: 10.1016/j.apsb.2021.05.018. Epub 2021 Jun 16. Acta Pharm Sin B. 2021. PMID: 35024320 Free PMC article.
98 results