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The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer.
Kazantseva M, Mehta S, Eiholzer RA, Gimenez G, Bowie S, Campbell H, Reily-Bell AL, Roth I, Ray S, Drummond CJ, Reid G, Joruiz SM, Wiles A, Morrin HR, Reader KL, Hung NA, Baird MA, Slatter TL, Braithwaite AW. Kazantseva M, et al. Among authors: joruiz sm. Cell Death Dis. 2019 Aug 20;10(9):631. doi: 10.1038/s41419-019-1861-1. Cell Death Dis. 2019. PMID: 31431617 Free PMC article.
TP53 drives invasion through expression of its Δ133p53β variant.
Gadea G, Arsic N, Fernandes K, Diot A, Joruiz SM, Abdallah S, Meuray V, Vinot S, Anguille C, Remenyi J, Khoury MP, Quinlan PR, Purdie CA, Jordan LB, Fuller-Pace FV, de Toledo M, Cren M, Thompson AM, Bourdon JC, Roux P. Gadea G, et al. Among authors: joruiz sm. Elife. 2016 Sep 15;5:e14734. doi: 10.7554/eLife.14734. Elife. 2016. PMID: 27630122 Free PMC article.
p53 Isoforms: Key Regulators of the Cell Fate Decision.
Joruiz SM, Bourdon JC. Joruiz SM, et al. Cold Spring Harb Perspect Med. 2016 Aug 1;6(8):a026039. doi: 10.1101/cshperspect.a026039. Cold Spring Harb Perspect Med. 2016. PMID: 26801896 Free PMC article. Review.
The Δ133p53 Isoforms, Tuners of the p53 Pathway.
Joruiz SM, Beck JA, Horikawa I, Harris CC. Joruiz SM, et al. Cancers (Basel). 2020 Nov 18;12(11):3422. doi: 10.3390/cancers12113422. Cancers (Basel). 2020. PMID: 33218139 Free PMC article. Review.