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Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia.
Pollyea DA, Stevens BM, Jones CL, Winters A, Pei S, Minhajuddin M, D'Alessandro A, Culp-Hill R, Riemondy KA, Gillen AE, Hesselberth JR, Abbott D, Schatz D, Gutman JA, Purev E, Smith C, Jordan CT. Pollyea DA, et al. Among authors: jordan ct. Nat Med. 2018 Dec;24(12):1859-1866. doi: 10.1038/s41591-018-0233-1. Epub 2018 Nov 12. Nat Med. 2018. PMID: 30420752 Free PMC article.
Cancer stem cells.
Jordan CT, Guzman ML, Noble M. Jordan CT, et al. N Engl J Med. 2006 Sep 21;355(12):1253-61. doi: 10.1056/NEJMra061808. N Engl J Med. 2006. PMID: 16990388 Review. No abstract available.
Targeting myeloid leukemia stem cells.
Jordan CT. Jordan CT. Sci Transl Med. 2010 May 12;2(31):31ps21. doi: 10.1126/scitranslmed.3000914. Sci Transl Med. 2010. PMID: 20463365 Review.
How close are we to targeting the leukemia stem cell?
Pei S, Jordan CT. Pei S, et al. Among authors: jordan ct. Best Pract Res Clin Haematol. 2012 Dec;25(4):415-8. doi: 10.1016/j.beha.2012.10.003. Epub 2012 Oct 23. Best Pract Res Clin Haematol. 2012. PMID: 23200537 Review.
BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells.
Lagadinou ED, Sach A, Callahan K, Rossi RM, Neering SJ, Minhajuddin M, Ashton JM, Pei S, Grose V, O'Dwyer KM, Liesveld JL, Brookes PS, Becker MW, Jordan CT. Lagadinou ED, et al. Among authors: jordan ct. Cell Stem Cell. 2013 Mar 7;12(3):329-41. doi: 10.1016/j.stem.2012.12.013. Epub 2013 Jan 17. Cell Stem Cell. 2013. PMID: 23333149 Free PMC article.
Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.
Pei S, Minhajuddin M, Callahan KP, Balys M, Ashton JM, Neering SJ, Lagadinou ED, Corbett C, Ye H, Liesveld JL, O'Dwyer KM, Li Z, Shi L, Greninger P, Settleman J, Benes C, Hagen FK, Munger J, Crooks PA, Becker MW, Jordan CT. Pei S, et al. Among authors: jordan ct. J Biol Chem. 2013 Nov 22;288(47):33542-33558. doi: 10.1074/jbc.M113.511170. Epub 2013 Oct 2. J Biol Chem. 2013. PMID: 24089526 Free PMC article. Clinical Trial.
Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity.
Callahan KP, Minhajuddin M, Corbett C, Lagadinou ED, Rossi RM, Grose V, Balys MM, Pan L, Jacob S, Frontier A, Grever MR, Lucas DM, Kinghorn AD, Liesveld JL, Becker MW, Jordan CT. Callahan KP, et al. Among authors: jordan ct. Leukemia. 2014 Oct;28(10):1960-8. doi: 10.1038/leu.2014.93. Epub 2014 Feb 28. Leukemia. 2014. PMID: 24577530 Free PMC article.
Aldehyde dehydrogenases in acute myeloid leukemia.
Smith C, Gasparetto M, Humphries K, Pollyea DA, Vasiliou V, Jordan CT. Smith C, et al. Among authors: jordan ct. Ann N Y Acad Sci. 2014 Mar;1310:58-68. doi: 10.1111/nyas.12414. Ann N Y Acad Sci. 2014. PMID: 24641679 Review.
190 results