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191 results

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MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity.
Lee-Sherick AB, Jacobsen KM, Henry CJ, Huey MG, Parker RE, Page LS, Hill AA, Wang X, Frye SV, Earp HS, Jordan CT, DeRyckere D, Graham DK. Lee-Sherick AB, et al. Among authors: jordan ct. JCI Insight. 2018 Nov 2;3(21):e97941. doi: 10.1172/jci.insight.97941. JCI Insight. 2018. PMID: 30385715 Free PMC article.
Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.
Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J. Alvarez-Calderon F, et al. Among authors: jordan ct. Clin Cancer Res. 2015 Mar 15;21(6):1360-72. doi: 10.1158/1078-0432.CCR-14-2146. Epub 2014 Dec 29. Clin Cancer Res. 2015. PMID: 25547679 Free PMC article.
The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia.
Minson KA, Smith CC, DeRyckere D, Libbrecht C, Lee-Sherick AB, Huey MG, Lasater EA, Kirkpatrick GD, Stashko MA, Zhang W, Jordan CT, Kireev D, Wang X, Frye SV, Earp HS, Shah NP, Graham DK. Minson KA, et al. Among authors: jordan ct. JCI Insight. 2016 Mar;1(3):e85630. doi: 10.1172/jci.insight.85630. JCI Insight. 2016. PMID: 27158668 Free PMC article.
MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity.
Lee-Sherick AB, Jacobsen KM, Henry CJ, Huey MG, Parker RE, Page LS, Hill AA, Wang X, Frye SV, Earp HS, Jordan CT, DeRyckere D, Graham DK. Lee-Sherick AB, et al. Among authors: jordan ct. JCI Insight. 2020 Dec 3;5(23):e145847. doi: 10.1172/jci.insight.145847. JCI Insight. 2020. PMID: 33268596 Free PMC article. No abstract available.
ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.
Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J. Gregory MA, et al. Among authors: jordan ct. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6669-E6678. doi: 10.1073/pnas.1603876113. Epub 2016 Oct 10. Proc Natl Acad Sci U S A. 2016. PMID: 27791036 Free PMC article.
Therapeutic targeting of acute myeloid leukemia stem cells.
Pollyea DA, Jordan CT. Pollyea DA, et al. Among authors: jordan ct. Blood. 2017 Mar 23;129(12):1627-1635. doi: 10.1182/blood-2016-10-696039. Epub 2017 Feb 3. Blood. 2017. PMID: 28159738 Free article. Review.
Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.
Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT. Jones CL, et al. Among authors: jordan ct. Cancer Cell. 2018 Nov 12;34(5):724-740.e4. doi: 10.1016/j.ccell.2018.10.005. Cancer Cell. 2018. PMID: 30423294 Free PMC article.
Targeting Glutamine Metabolism and Redox State for Leukemia Therapy.
Gregory MA, Nemkov T, Park HJ, Zaberezhnyy V, Gehrke S, Adane B, Jordan CT, Hansen KC, D'Alessandro A, DeGregori J. Gregory MA, et al. Among authors: jordan ct. Clin Cancer Res. 2019 Jul 1;25(13):4079-4090. doi: 10.1158/1078-0432.CCR-18-3223. Epub 2019 Apr 2. Clin Cancer Res. 2019. PMID: 30940653 Free PMC article.
191 results