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Practical Aspects of Designing and Conducting Validation Studies Involving Multi-study Trials.
Coecke S, Bernasconi C, Bowe G, Bostroem AC, Burton J, Cole T, Fortaner S, Gouliarmou V, Gray A, Griesinger C, Louhimies S, Gyves EM, Joossens E, Prinz MJ, Milcamps A, Parissis N, Wilk-Zasadna I, Barroso J, Desprez B, Langezaal I, Liska R, Morath S, Reina V, Zorzoli C, Zuang V. Coecke S, et al. Among authors: joossens e. Adv Exp Med Biol. 2016;856:133-163. doi: 10.1007/978-3-319-33826-2_5. Adv Exp Med Biol. 2016. PMID: 27671721 Review.
Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making.
Paini A, Leonard JA, Joossens E, Bessems JGM, Desalegn A, Dorne JL, Gosling JP, Heringa MB, Klaric M, Kliment T, Kramer NI, Loizou G, Louisse J, Lumen A, Madden JC, Patterson EA, Proença S, Punt A, Setzer RW, Suciu N, Troutman J, Yoon M, Worth A, Tan YM. Paini A, et al. Among authors: joossens e. Comput Toxicol. 2019 Feb;9:61-72. doi: 10.1016/j.comtox.2018.11.002. Comput Toxicol. 2019. PMID: 31008414 Free PMC article. Review.
The virtual cell based assay: Current status and future perspectives.
Graepel R, Lamon L, Asturiol D, Berggren E, Joossens E, Paini A, Prieto P, Whelan M, Worth A. Graepel R, et al. Among authors: joossens e. Toxicol In Vitro. 2017 Dec;45(Pt 2):258-267. doi: 10.1016/j.tiv.2017.01.009. Epub 2017 Jan 18. Toxicol In Vitro. 2017. PMID: 28108195 Free PMC article.
Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity.
Ahlberg E, Amberg A, Beilke LD, Bower D, Cross KP, Custer L, Ford KA, Van Gompel J, Harvey J, Honma M, Jolly R, Joossens E, Kemper RA, Kenyon M, Kruhlak N, Kuhnke L, Leavitt P, Naven R, Neilan C, Quigley DP, Shuey D, Spirkl HP, Stavitskaya L, Teasdale A, White A, Wichard J, Zwickl C, Myatt GJ. Ahlberg E, et al. Among authors: joossens e. Regul Toxicol Pharmacol. 2016 Jun;77:1-12. doi: 10.1016/j.yrtph.2016.02.003. Epub 2016 Feb 13. Regul Toxicol Pharmacol. 2016. PMID: 26879463
Microscopy-based high-throughput assays enable multi-parametric analysis to assess adverse effects of nanomaterials in various cell lines.
Hansjosten I, Rapp J, Reiner L, Vatter R, Fritsch-Decker S, Peravali R, Palosaari T, Joossens E, Gerloff K, Macko P, Whelan M, Gilliland D, Ojea-Jimenez I, Monopoli MP, Rocks L, Garry D, Dawson K, Röttgermann PJF, Murschhauser A, Rädler JO, Tang SVY, Gooden P, Belinga-Desaunay MA, Khan AO, Briffa S, Guggenheim E, Papadiamantis A, Lynch I, Valsami-Jones E, Diabaté S, Weiss C. Hansjosten I, et al. Among authors: joossens e. Arch Toxicol. 2018 Feb;92(2):633-649. doi: 10.1007/s00204-017-2106-7. Epub 2017 Nov 8. Arch Toxicol. 2018. PMID: 29119250
MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma.
Sadones J, Michotte A, Veld P, Chaskis C, Sciot R, Menten J, Joossens EJ, Strauven T, D'Hondt LA, Sartenaer D, Califice SF, Bierau K, Svensson C, De Grève J, Neyns B. Sadones J, et al. Among authors: joossens ej. Eur J Cancer. 2009 Jan;45(1):146-53. doi: 10.1016/j.ejca.2008.09.002. Epub 2008 Oct 20. Eur J Cancer. 2009. PMID: 18945611
15 results