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Pharmacological inhibition of MEK1/2 signaling disrupts bile acid metabolism through loss of Shp and enhanced Cyp7a1 expression.
Verzijl CRC, van de Peppel IP, Eilers RE, Bloks VW, Wolters JC, Koehorst M, Kloosterhuis NJ, Havinga R, Jalving M, Struik D, Jonker JW. Verzijl CRC, et al. Among authors: jonker jw. Biomed Pharmacother. 2023 Mar;159:114270. doi: 10.1016/j.biopha.2023.114270. Epub 2023 Jan 19. Biomed Pharmacother. 2023. PMID: 36680812 Free article.
The chemotherapeutic drug doxorubicin does not exacerbate p16Ink4a-positive senescent cell accumulation and cardiometabolic disease development in young adult female LDLR-deficient mice.
Postmus AC, Kruit JK, Eilers RE, Havinga R, Koster MH, Johmura Y, Nakanishi M, van de Sluis B, Jonker JW. Postmus AC, et al. Among authors: jonker jw. Toxicol Appl Pharmacol. 2023 Jun 1;468:116531. doi: 10.1016/j.taap.2023.116531. Epub 2023 Apr 23. Toxicol Appl Pharmacol. 2023. PMID: 37088304 Free article.
Rebalancing of mitochondrial homeostasis through an NAD+-SIRT1 pathway preserves intestinal barrier function in severe malnutrition.
Ling C, Versloot CJ, Arvidsson Kvissberg ME, Hu G, Swain N, Horcas-Nieto JM, Miraglia E, Thind MK, Farooqui A, Gerding A, van Eunen K, Koster MH, Kloosterhuis NJ, Chi L, ChenMi Y, Langelaar-Makkinje M, Bourdon C, Swann J, Smit M, de Bruin A, Youssef SA, Feenstra M, van Dijk TH, Thedieck K, Jonker JW, Kim PK, Bakker BM, Bandsma RHJ. Ling C, et al. Among authors: jonker jw. EBioMedicine. 2023 Oct;96:104809. doi: 10.1016/j.ebiom.2023.104809. Epub 2023 Sep 20. EBioMedicine. 2023. PMID: 37738832 Free PMC article.
Inhibition of mTOR improves malnutrition induced hepatic metabolic dysfunction.
Arvidsson Kvissberg ME, Hu G, Chi L, Bourdon C, Ling C, ChenMi Y, Germain K, van Peppel IP, Weise L, Zhang L, Di Giovanni V, Swain N, Jonker JW, Kim P, Bandsma R. Arvidsson Kvissberg ME, et al. Among authors: jonker jw. Sci Rep. 2022 Nov 19;12(1):19948. doi: 10.1038/s41598-022-24428-7. Sci Rep. 2022. PMID: 36402829 Free PMC article.
Failure to repair endogenous DNA damage in β-cells causes adult-onset diabetes in mice.
Yousefzadeh MJ, Huerta Guevara AP, Postmus AC, Flores RR, Sano T, Jurdzinski A, Angelini L, McGowan SJ, O'Kelly RD, Wade EA, Gonzalez-Espada LV, Henessy-Wack D, Howard S, Rozgaja TA, Trussoni CE, LaRusso NF, Eggen BJL, Jonker JW, Robbins PD, Niedernhofer LJ, Kruit JK. Yousefzadeh MJ, et al. Among authors: jonker jw. Aging Biol. 2023;1(1):20230015. doi: 10.59368/agingbio.20230015. Epub 2023 Oct 23. Aging Biol. 2023. PMID: 38124711 Free PMC article.
Identification of an alternative triglyceride biosynthesis pathway.
McLelland GL, Lopez-Osias M, Verzijl CRC, Ellenbroek BD, Oliveira RA, Boon NJ, Dekker M, van den Hengel LG, Ali R, Janssen H, Song JY, Krimpenfort P, van Zutphen T, Jonker JW, Brummelkamp TR. McLelland GL, et al. Among authors: jonker jw. Nature. 2023 Sep;621(7977):171-178. doi: 10.1038/s41586-023-06497-4. Epub 2023 Aug 30. Nature. 2023. PMID: 37648867 Free PMC article.
Activation of Liver X Receptors and Peroxisome Proliferator-Activated Receptors by Lipid Extracts of Brown Seaweeds: A Potential Application in Alzheimer's Disease?
Martens N, Zhan N, Voortman G, Leijten FPJ, van Rheenen C, van Leerdam S, Geng X, Huybrechts M, Liu H, Jonker JW, Kuipers F, Lütjohann D, Vanmierlo T, Mulder MT. Martens N, et al. Among authors: jonker jw. Nutrients. 2023 Jun 30;15(13):3004. doi: 10.3390/nu15133004. Nutrients. 2023. PMID: 37447330 Free PMC article.
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